Ligand-Enabled Alkynylation of C(sp3)-H Bonds with Palladium(II) Catalysts

被引：48

作者：

Fu, Haiyan ^{[1
]}

Shen, Peng-Xiang ^{[1
]}

He, Jian ^{[1
]}

Zhang, Fanglin ^{[1
]}

Li, Suhua ^{[1
]}

Wang, Peng ^{[1
]}

Liu, Tao ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 07期

关键词：

alkynylation; amino acids; C-H activation; palladium; pyridine; C-H ALKYNYLATION; ALPHA-AMINO-ACIDS; ROOM-TEMPERATURE; TERMINAL ALKYNES; CHELATION-ASSISTANCE; C(SP(2))-H BONDS; DIRECTING GROUP; MILD CONDITIONS; DERIVATIVES; ACTIVATION;

D O I：

10.1002/anie.201610426

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The palladium(II)-catalyzed beta-and-alkynylation of amide C(sp(3))-H bonds is enabled by pyridine-based ligands. This alkynylation reaction is compatible with substrates containing alpha-tertiary or alpha-quaternary carbon centers. The beta-methylene C(sp(3))-H bonds of various carbocyclic rings were also successfully alkynylated.

引用

页码：1873 / 1876

页数：4

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