Left Ventricular Hypertrophy Is Associated With Increased Infarct Size and Decreased Myocardial Salvage in Patients With ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

被引:41
作者
Nepper-Christensen, Lars [1 ]
Lonborg, Jacob [1 ]
Ahtarovski, Kiril Aleksov [1 ]
Hofsten, Dan Eik [1 ]
Kyhl, Kasper [1 ]
Ghotbi, Adam Ali [1 ]
Schoos, Mikkel Malby [1 ,2 ]
Goransson, Christoffer [1 ]
Bertelsen, Litten [1 ]
Kober, Lars [1 ]
Helqvist, Steffen [1 ]
Pedersen, Frants [1 ]
Saunamaki, Kari [1 ]
Jorgensen, Erik [1 ]
Kelbaek, Henning [2 ]
Holmvang, Lene [1 ]
Vejlstrup, Niels [1 ]
Engstrom, Thomas [1 ]
机构
[1] Copenhagen Univ Hosp, Rigshosp, Dept Cardiol, Copenhagen, Denmark
[2] Zealand Univ Hosp, Dept Cardiol, Roskilde, Denmark
来源
JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2017年 / 6卷 / 01期
关键词
cardiac magnetic resonance imaging; left ventricular hypertrophy; myocardial infarction; primary percutaneous coronary intervention; ST-segment elevation myocardial infarction; CARDIOVASCULAR MAGNETIC-RESONANCE; CONTRAST-ENHANCED CMR; CHRONIC HYPERTENSION; PROGNOSTIC IMPLICATIONS; QUANTITATIVE ASSESSMENT; REPERFUSION INJURY; RISK; AREA; HEART; MASS;
D O I
10.1161/JAHA.116.004823
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background-Approximately one third of patients with ST-segment elevation myocardial infarction (STEMI) have left ventricular hypertrophy (LVH), which is associated with impaired outcome. However, the causal association between LVH and outcome in STEMI is unknown. We evaluated the association between LVH and: myocardial infarct size, area at risk, myocardial salvage, microvascular obstruction, left ventricular (LV) function (all determined by cardiac magnetic resonance [CMR]), and all-cause mortality and readmission for heart failure in STEMI patients treated with primary percutaneous coronary intervention. Methods and Results-In this substudy of the DANAMI-3 trial, 764 patients underwent CMR. LVH was defined by CMR and considered present if LV mass exceeded 77 (men) and 67 g/m(2) (women). One hundred seventy-eight patients (24%) had LVH. LVH was associated with a larger final infarct size (15% [interquartile range {IQR}, 10-21] vs 9% [IQR, 3-17]; P< 0.001) and smaller final myocardial salvage index (0.6 [IQR, 0.5-0.7] vs 0.7 [IQR, 0.5-0.9]; P< 0.001). The LVH group had a higher incidence of microvascular obstruction (66% vs 45%; P< 0.001) and lower final LV ejection fraction (LVEF; 53% [IQR, 47-60] vs 61% [ IQR, 55-65]; P< 0.001). In a Cox regression analysis, LVH was associated with a higher risk of all-cause mortality and readmission for heart failure (hazard ratio 2.59 [95% CI, 1.38-4.90], P=0.003). The results remained statistically significant in multivariable models. Conclusions-LVH is independently associated with larger infarct size, less myocardial salvage, higher incidence of microvascular obstruction, lower LVEF, and a higher risk of all-cause mortality and incidence of heart failure in STEMI patients treated with primary percutaneous coronary intervention.
引用
收藏
页数:14
相关论文
共 50 条
[41]   The relationship between epicardial adipose tissue and ST-segment resolution in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention [J].
Zencirci, Ertugrul ;
Zencirci, Aycan Esen ;
Degirmencioglu, Aleks ;
Karakus, Gultekin ;
Ugurlucan, Murat ;
Ozden, Kivilcim ;
Erdem, Aysun ;
Gullu, Ahmet Umit ;
Ekmekci, Ahmet ;
Velibey, Yalcin ;
Erer, Hatice Betul ;
Celik, Seden ;
Akyol, Ahmet .
HEART AND VESSELS, 2015, 30 (02) :147-153
[42]   Cardioprotective Effects of Intracoronary Morphine in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention: A Prospective, Randomized Trial [J].
Gwag, Hye Bin ;
Kim, Eun Kyoung ;
Park, Taek Kyu ;
Lee, Joo Myung ;
Yang, Jeong Hoon ;
Song, Young Bin ;
Choi, Jin-Ho ;
Choi, Seung-Hyuk ;
Lee, Sang Hoon ;
Chang, Sung-A ;
Park, Sung-Ji ;
Lee, Sang-Chol ;
Park, Seung Woo ;
Jang, Woo Jin ;
Lee, Mirae ;
Chun, Woo Jung ;
Oh, Ju Hyeon ;
Park, Yong Hwan ;
Choe, Yeon Hyeon ;
Gwon, Hyeon-Cheol ;
Hahn, Joo-Yong .
JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2017, 6 (04)
[43]   Impact of Primary Coronary Angioplasty Delay on Myocardial Salvage, Infarct Size, and Microvascular Damage in Patients With ST-Segment Elevation Myocardial Infarction Insight From Cardiovascular Magnetic Resonance [J].
Francone, Marco ;
Bucciarelli-Ducci, Chiara ;
Carbone, Iacopo ;
Canali, Emanuele ;
Scardala, Raffaele ;
Calabrese, Francesca A. ;
Sardella, Gennaro ;
Mancone, Massimo ;
Catalano, Carlo ;
Fedele, Francesco ;
Passariello, Roberto ;
Bogaert, Jan ;
Agati, Luciano .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (23) :2145-2153
[44]   Effect of intracoronary tirofiban following aspiration thrombectomy on infarct size, in patients with large anterior ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention [J].
Basuoni, Ahmed ;
El-Naggar, Wael ;
Mahdy, Mohamed ;
Al-Kaffas, Sameh .
CORONARY ARTERY DISEASE, 2020, 31 (03) :255-259
[45]   Metabolomic characterization of myocardial ischemia-reperfusion injury in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention [J].
Surendran, Arun ;
Aliani, Michel ;
Ravandi, Amir .
SCIENTIFIC REPORTS, 2019, 9 (1)
[46]   TICAGRELOR FOR PATIENTS WITH ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION AFTER EMERGENCY PERCUTANEOUS CORONARY INTERVENTION [J].
Han, L. ;
Zhang, J. J. ;
Jing, H. F. ;
Qin, L. .
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2019, 33 (02) :485-490
[47]   Transfusion and mortality in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention [J].
Jolicoeur, E. Marc ;
O'Neill, William W. ;
Hellkamp, Anne ;
Hamm, Christian W. ;
Holmes, David R., Jr. ;
Al-Khalidi, Hussein R. ;
Patel, Manesh R. ;
Van de Werf, Frans J. ;
Pieper, Karen ;
Armstrong, Paul W. ;
Granger, Christopher B. .
EUROPEAN HEART JOURNAL, 2009, 30 (21) :2575-2583
[48]   Primary Percutaneous Coronary Intervention as a National Reperfusion Strategy in Patients With ST-Segment Elevation Myocardial Infarction [J].
Terkelsen, Christian J. ;
Jensen, Lisette O. ;
Tilsted, Hans H. ;
Thaysen, Per ;
Ravkilde, Jan ;
Johnsen, Soren P. ;
Trautner, Sven ;
Andersen, Henning R. ;
Thuesen, Leif ;
Lassen, Jens F. .
CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2011, 4 (06) :570-576
[49]   QT-interval evaluation in primary percutaneous coronary intervention of ST-segment elevation myocardial infarction for prediction of myocardial salvage index [J].
Guaricci, Andrea Igoren ;
Carita, Patrizia ;
Lorenzoni, Valentina ;
Casavecchia, GraziaPia ;
Rabbat, Mark ;
Ieva, Riccardo ;
Brunetti, Natale Daniele ;
Andreini, Daniele ;
Di Biase, Matteo ;
Marenzi, Giancarlo ;
Bartorelli, Antonio ;
Pepi, Mauro ;
Pontone, Gianluca .
PLOS ONE, 2018, 13 (02)
[50]   Role of leukocyte parameters in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention with high thrombus burden [J].
Wang, Hao ;
Li, Shixing ;
Yu, Jin ;
Xu, Jingsong ;
Xu, Yan .
FRONTIERS IN CARDIOVASCULAR MEDICINE, 2024, 11