Stem cells and modeling of autism spectrum disorders

被引：9

作者：

Freitas, Beatriz C. G. ^{[1
]}

Trujillo, Cleber A. ^{[1
]}

Carromeu, Cassiano ^{[1
]}

Yusupova, Marianna ^{[1
]}

Herai, Roberto H. ^{[1
]}

Muotri, Alysson R. ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Pediat,Stem Cell Program, Rady Childrens Hosp San Diego,Dept Cellular & Mol, La Jolla, CA 92093 USA

来源：

EXPERIMENTAL NEUROLOGY | 2014年 / 260卷

基金：

美国国家卫生研究院;

关键词：

Autism spectrum disorders; Stem cells; Induced pluripotent stem cells; Animal model; Fragile X syndrome; Rett syndrome; Angelman syndrome; Timothy syndrome; Genomic editing; COPY NUMBER VARIATION; FRAGILE-X-SYNDROME; FMR1 KNOCKOUT MICE; MOUSE MODEL; RETT-SYNDROME; PREFRONTAL CORTEX; ANGELMAN-SYNDROME; SMALL MOLECULES; SELF-RENEWAL; IPS CELLS;

D O I：

10.1016/j.expneurol.2012.09.017

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Human neurons, generated from reprogrammed somatic cells isolated from live patients, bring a new perspective on the understanding of Autism Spectrum Disorders (ASD). The new technology can nicely complement other models for basic research and the development of therapeutic compounds aiming to revert or ameliorate the condition. Here, we discuss recent advances on the use of stem cells and other models to study ASDs, as well as their limitations, implications and future perspectives. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：33 / 43

页数：11

共 156 条

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