Non-Coding RNAs, a Novel Paradigm for the Management of Gastrointestinal Stromal Tumors

被引:7
作者
Amirnasr, Azadeh [1 ]
Sleijfer, Stefan [1 ]
Wiemer, Erik A. C. [1 ]
机构
[1] Erasmus MC, Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 CN Rotterdam, Netherlands
关键词
microRNA; long non-coding RNAs; GIST; biomarker; therapy; V600E BRAF MUTATIONS; DOWN-REGULATION; IMATINIB RESISTANCE; INTERSTITIAL-CELLS; PDGFRA MUTATIONS; SUCCINATE-DEHYDROGENASE; CIRCULATING MICRORNA; POTENTIAL BIOMARKER; EXPRESSION PROFILE; ADJUVANT IMATINIB;
D O I
10.3390/ijms21186975
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal malignancies found in the gastrointestinal tract. At a molecular level, most GISTs are characterized by gain-of-function mutations in V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog (KIT) and Platelet Derived Growth Factor Receptor Alpha (PDGFRA), leading to constitutive activated signaling through these receptor tyrosine kinases, which drive GIST pathogenesis. In addition to surgery, treatment with the tyrosine kinase inhibitor imatinib forms the mainstay of GIST treatment, particularly in the advanced setting. Nevertheless, the majority of GISTs develop imatinib resistance. Biomarkers that indicate metastasis, drug resistance and disease progression early on could be of great clinical value. Likewise, novel treatment strategies that overcome resistance mechanisms are equally needed. Non-coding RNAs, particularly microRNAs, can be employed as diagnostic, prognostic or predictive biomarkers and have therapeutic potential. Here we review which non-coding RNAs are deregulated in GISTs, whether they can be linked to specific clinicopathological features and discuss how they can be used to improve the clinical management of GISTs.
引用
收藏
页码:1 / 23
页数:25
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