The implication of hepatokines in metabolic syndrome

被引：16
作者：
Esfahani, Maryam [1 ]
Baranchi, Mostafa [2 ]
Goodarzi, Mohammad Taghi [3 ]
机构：
[1] Hamedan Univ Med Sci, Hamadan, Iran
[2] Tarbiat Modares Univ, Tehran, Iran
[3] Hamadan Univ Med Sci, Res Ctr Mol Med, Hamadan, Iran
来源：
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS | 2019年 / 13卷 / 04期
关键词：
Metabolic syndrome; Hepatokines; Insulin resistance; Dyslipidemia; Hypertension; GROWTH-FACTOR; 21; CARDIOVASCULAR RISK-FACTORS; ANGIOPOIETIN-LIKE; 4; FETUIN-A; INSULIN-RESISTANCE; SELENOPROTEIN P; SERUM-LEVELS; BETATROPHIN CONCENTRATIONS; HEPATIC STEATOSIS; OBESITY;
D O I：
10.1016/j.dsx.2019.06.027
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Hepatokines are liver-derived proteins with equivocal roles in metabolic syndrome (MetS). These proteins have prominent role in pathogenesis of MetS component such as obesity, insulin resistance, dyslipidemia and hypertension. The identification and functional characterization of hepatokines may provide significant insights that could help in better understanding of MetS pathogenesis. Fetuin-A, Hepatocyte-derived fibrinogen-related protein 1, Fibroblast growth factor 21, Angiopoietin-related growth factor, Selenoprotein-P, Angiopoietin like proteins, Leukocyte cell-derived chemotaxin 2 are regarded as the most significant hepatokines. We describe recent data on these new hormones in progression of MetS. Understanding of the accurate role of these proteins in pathophysiology of MetS can help improving prevention and treatment of this syndrome. (C) 2019 Diabetes India. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：2477 / 2480
页数：4
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