Autism Spectrum Disorder Risk in Relation to Maternal Mid-Pregnancy Serum Hormone and Protein Markers from Prenatal Screening in California

被引：23
作者：
Windham, Gayle C. [1 ]
Lyall, Kristen [1 ,4 ]
Anderson, Meredith [2 ]
Kharrazi, Martin [1 ,3 ]
机构：
[1] Environm Hlth Invest Branch, Div Environm & Occupat Dis Control, Calif Dept Publ Hlth, 850 Marina Bay Pkwy, Richmond, CA 94804 USA
[2] Impact Assessment Inc, 2166 Ave Playa,Suite F, La Jolla, CA 92037 USA
[3] Genet Dis Screening Program, Calif Dept Publ Hlth, 850 Marina Bay Pkwy, Richmond, CA 94804 USA
[4] Drexel Univ, AJ Drexel Autism Inst, Philadelphia, PA 19104 USA
来源：
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2016年 / 46卷 / 02期
关键词：
Autism spectrum disorder; Steroid hormones; Estrogen; Alpha-fetoprotein; hCG; Prenatal screening; Estriol; HUMAN CHORIONIC-GONADOTROPIN; MALE BRAIN THEORY; FETAL TESTOSTERONE; ALPHA-FETOPROTEIN; ENVIRONMENTAL-FACTORS; UNCONJUGATED ESTRIOL; INCREASED PREVALENCE; ESTROGEN ACTION; CHILDREN BORN; DOWN-SYNDROME;
D O I：
10.1007/s10803-015-2587-2
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
We examined prenatal screening markers and offspring autism spectrum disorder (ASD) using California statewide data on singleton births in 1996 and 2002. Second trimester levels of unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and maternal serum alpha-fetoprotein (MSAFP) were compared between mothers of children with ASD (n = 2586) and of non-cases (n = 600,103). Adjusted odds ratios (AOR) were calculated by logistic regression. Lower uE3 (AOR for < 10th percentile vs. 25th-74th percentiles = 1.21, 95 % CI 1.06-1.37), and higher MSAFP (AOR = 1.21, 95 % CI 1.07-1.37 for > 90th percentile) were significantly associated with ASD. A U-shaped relationship was seen for hCG (AOR = 1.16, 95 % CI 1.02-1.32 for < 10th percentile; AOR = 1.19, 95 % CI 1.05-1.36 for > 90th percentile). Our results further support prenatal hormone involvement in ASD risk.
引用
收藏
页码：478 / 488
页数：11
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