Genotoxicity and transmission electron microscopy studies of molybdocene dichloride

被引：8

作者：

Campbell, Kate S.

Foster, Amalanie J.

Dillon, Carolyn T. ^{[1
]}

Harding, Margaret. M.

机构：

[1] Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia

[2] Univ Wollongong, Dept Chem, Wollongong, NSW 2522, Australia

[3] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2006年 / 100卷 / 07期

关键词：

molybdocene dichloride; antitumor metallocene; genotoxicity; micronucleus assay; TEM;

D O I：

10.1016/j.jinorgbio.2006.01.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytotoxic effects of molybdocene dichloride (CP2MoCl2) were investigated in V79 Chinese hamster lung cells using the micronucleus assay. CP2MoCl2 produced significant genotoxic damage whereby 0.2 micronuclei/1000 binucleated cells were induced per mu M of Cp2MoCl2. Transmission electron microscopic analysis of thin-sectioned cells treated with Cp2MoCl2 (300 mu M) showed distinct morphological alterations of the nuclei, condensation of chromatin, and a high incidence of polynucleated cells. Implications for the mechanism of antitumor action of molybdocene dichloride are discussed. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1194 / 1198

页数：5

共 27 条

[21] ORGANOMETALLIC ANTICANCER AGENTS - THE EFFECT OF THE CENTRAL METAL AND HALIDE LIGANDS ON THE INTERACTION OF METALLOCENE DIHALIDES CP(2)MX(2) WITH NUCLEIC-ACID CONSTITUENTS [J].