Genotoxicity and transmission electron microscopy studies of molybdocene dichloride

被引：8
作者：
Campbell, Kate S.
Foster, Amalanie J.
Dillon, Carolyn T. [1 ]
Harding, Margaret. M.
机构：
[1] Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia
[2] Univ Wollongong, Dept Chem, Wollongong, NSW 2522, Australia
[3] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2006年 / 100卷 / 07期
关键词：
molybdocene dichloride; antitumor metallocene; genotoxicity; micronucleus assay; TEM;
D O I：
10.1016/j.jinorgbio.2006.01.034
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The cytotoxic effects of molybdocene dichloride (CP2MoCl2) were investigated in V79 Chinese hamster lung cells using the micronucleus assay. CP2MoCl2 produced significant genotoxic damage whereby 0.2 micronuclei/1000 binucleated cells were induced per mu M of Cp2MoCl2. Transmission electron microscopic analysis of thin-sectioned cells treated with Cp2MoCl2 (300 mu M) showed distinct morphological alterations of the nuclei, condensation of chromatin, and a high incidence of polynucleated cells. Implications for the mechanism of antitumor action of molybdocene dichloride are discussed. (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：1194 / 1198
页数：5
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