A facile protocol for the synthesis of 3-aminoimidazo-fused heterocycles via the Groebke-Blackburn-Bienayme reaction under catalyst-free and solvent-free conditions

被引：96

作者：

Vidyacharan, Shinde ^{[1
]}

Shinde, Anand H. ^{[1
]}

Satpathi, Bishnupada ^{[1
]}

Sharada, Duddu S. ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Hyderabad 502205, Andhra Pradesh, India

来源：

GREEN CHEMISTRY | 2014年 / 16卷 / 03期

关键词：

MULTICOMPONENT REACTIONS; 3-COMPONENT CONDENSATION; REGIOSELECTIVE SYNTHESIS; ANNULATED PYRIDINES; BENIGN SYNTHESIS; CHEMISTRY; PYRAZINES; CONSTRUCTION; PYRIMIDINES; INHIBITORS;

D O I：

10.1039/c3gc42130a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot catalyst, solvent, work-up and column free synthesis of 3-aminoimidazo-fused heterocycles by a three-component reaction of a 2-aminoheterocycle, aldehyde, and isocyanide is presented. This efficient and green protocol has the advantages of environmental friendliness, high yields and operational simplicity.

引用

页码：1168 / 1175

页数：8

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