An ultrafast responsive BODIPY-based fluorescent probe for the detection of endogenous hypochlorite in live cells

被引：52

作者：

Qiao, Liang ^{[1
]}

Nie, Hailiang ^{[1
]}

Wu, Yulong ^{[1
]}

Xin, Fangyun ^{[1
]}

Gao, Congcong ^{[1
]}

Jing, Jing ^{[1
]}

Zhang, Xiaoling ^{[1
]}

机构：

[1] Beijing Inst Technol, Key Lab Cluster Sci, Beijing Key Lab Photoelect Electrophoton Convers, Sch Chem & Chem Engn,Minist Educ, Beijing 100081, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2017年 / 5卷 / 03期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

REAL WATER SAMPLES; LARGE STOKES SHIFT; LIVING CELLS; RAPID DETECTION; CANCER-CELLS; ACID; CHEMODOSIMETER; MYELOPEROXIDASE; MITOCHONDRIA; HYDRAZINE;

D O I：

10.1039/c6tb02774a

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Hypochlorite plays a significant role in various physiological and pathological processes; however, its role is still less clear than the role of other reactive oxygen species. Herein, we report an ultrafast responsive ( <0.2 s) and highly selective probe B-Ts for hypochlorite with high sensitivity and a detection limit as low as 7.5 nM. The probe was compatible in a wide pH range of 4-13. More importantly, experiments in live cells showed that the probe could penetrate the cell membrane easily and was capable of imaging endogenous and exogenous hypochlorite specifically with a fast response.

引用

页码：525 / 530

页数：6

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