Effects of Gold Nanoparticles on Erythrocyte Hemolysis

被引：34

作者：

Aseichev, A. V. ^{[1
]}

Azizova, O. A. ^{[1
]}

Beckman, E. M. ^{[1
]}

Skotnikova, O. I. ^{[1
]}

Dudnik, L. B. ^{[1
]}

Shcheglovitova, O. N. ^{[1
]}

Sergienko, V. I. ^{[1
]}

机构：

[1] Fed Biomed Agcy Russia, Res Inst Physicochem Med, Lab Biophys Bases Dis, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 156卷 / 04期

关键词：

erythrocytes; hemolysis; gold nanoparticles; TOXICITY; PROFILES; OXIDE; SIZE;

D O I：

10.1007/s10517-014-2383-6

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied hemolytic activity of gold nanoparticles added to the whole blood (ex vivo) and of nanoparticles coated and not coated with plasma components on erythrocytes in hypotonic medium (osmotic hemolysis) in vitro. Gold nanoparticles did not stimulate erythrocyte hemolysis after 4-h incubation with the whole blood ex vivo. Hemolysis tended to increase in the presence of small gold nanoparticles (5, 10, 20 nm) at the maximum concentration of 20 mu M (by gold content) used in our study in comparison with the control. This tendency was detected during the 1st hour of the nanoparticles incubation with blood. Gold nanoparticles in the used concentrations (up to 20 mu M of gold) coated with plasma components after preincubation with autologous plasma and nanoparticles without coating caused no osmotic hemolysis of erythrocytes in vitro.

引用

页码：495 / 498

页数：4

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