Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice

被引:55
作者
Yang, Bei [1 ]
Zou, Weiying [1 ]
Hu, Zhenzhen [2 ]
Liu, Fangming [3 ]
Zhou, Ling [4 ]
Yang, Shulong [1 ]
Kuang, Haibin [1 ]
Wu, Lei [1 ]
Wei, Jie [1 ]
Wang, Jinglei [1 ]
Zou, Ting [1 ]
Zhang, Dalei [1 ]
机构
[1] Nanchang Univ, Dept Physiol, Coll Med, Nanchang 330006, Peoples R China
[2] Nanchang Univ, Dept Pathophysiol, Coll Med, Nanchang 330006, Peoples R China
[3] Lib Nanchang Univ, Nanchang 330006, Peoples R China
[4] Nanchang Med Sch, Nanchang 330006, Peoples R China
基金
中国国家自然科学基金;
关键词
PERFLUOROALKYL CHEMICALS; PFOA; HEPATOCYTES; EXPRESSION; BIOMARKERS; DISEASE; TISSUES; DAMAGE; CELLS; DNA;
D O I
10.1155/2014/409837
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity in animals and humans. In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day). Histological examination showed that the exposure to PFOA for 14 consecutive days led to serious hepatocellular injury and obvious inflammatory cell infiltration. In addition, malondialdehyde formation and hydrogen peroxide generation, indicators of oxidative stress, were significantly induced by PFOA treatment in the liver of mice. Furthermore, hepatic levels of interleukin-6, cyclooxygenase-2, and C-reactive protein, markers of inflammatory response, were markedly increased by exposure to PFOA in mice. These results demonstrated that PFOA-induced hepatic toxicity may be involved in oxidative stress and inflammatory response in mice.
引用
收藏
页数:7
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