NT-pro-BNP in patients with left ventricular hypertrabeculation/non-compaction

被引:12
|
作者
Rapatz, Katharina [1 ]
Finsterer, Josef [1 ]
Voill-Glaninger, Astrid [1 ]
Wilfinger-Lutz, Nastasia [1 ]
Winkler-Dworak, Maria [2 ]
Stoellberger, Claudia [1 ]
机构
[1] Klin Landstr, Vienna, Austria
[2] Austrian Acad Sci, Vienna Inst Demog, Wittgenstein Ctr Demog & Global Human Capital, Vienna, Austria
来源
ESC HEART FAILURE | 2020年 / 7卷 / 06期
关键词
Heart failure; Cardiomyopathy; Echocardiography; Biomarkers; NATRIURETIC PEPTIDE; ATRIAL-FIBRILLATION; CARDIOMYOPATHY; PROGNOSIS;
D O I
10.1002/ehf2.13029
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aims Left ventricular hypertrabeculation/non-compaction (LVHT) is a cardiac abnormality of unknown pathogenesis and frequently associated with neuromuscular disorders. The N-terminal fragment of the pro brain natriuretic peptide (NT-pro-BNP) is a prognostic marker in heart failure whose relevance in LVHT patients is largely unknown. The aim of the study was to assess the role of NT-pro-BNP levels as prognostic markers in LVHT. Methods and results Data of LVHT patients were collected in a database from one echocardiographic laboratory since 1996. The hospital information system was screened for measurements of NT-pro-BNP levels, and their association with clinical and echocardiographic baseline parameters was retrospectively assessed. During follow-up, the endpoints were death and heart transplantation. In 113 patients (median age 57 years, 24% women), data about NT-pro-BNP measurements were found, ranging from 8 to 121 152 (median 2029) ng/L. High NT-pro-BNP levels were associated with heart failure, valvular abnormalities, diabetes mellitus, hypertension, angina pectoris, number of LVHT-affected segments, end-diastolic diameter, and systolic dysfunction. During a follow-up of 73 (+/- 64; 0-237) months, 35% of the patients reached an endpoint. High NT-pro-BNP levels were associated with the occurrence of an endpoint (P < 0.001). By multivariate analysis, predictors for endpoints were increased age (P = 0.0025), atrial fibrillation (P = 0.0023), natural logarithm of NT-pro-BNP levels (P = 0.0073), diabetes mellitus (P = 0.014), and thromboembolic events before diagnosis (P = 0.0347). Conclusions Also in LVHT patients, high NT-pro-BNP levels are indicators for death and heart transplantation.
引用
收藏
页码:4126 / 4133
页数:8
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