AMPK: Regulating Energy Balance at the Cellular and Whole Body Levels

被引：225

作者：

Hardie, D. Grahame ^{[1
]}

Ashford, Michael L. J.

机构：

[1] Univ Dundee, Coll Life Sci, Div Cell Signalling & Immunol, Dundee, Scotland

来源：

PHYSIOLOGY | 2014年 / 29卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

ACTIVATED PROTEIN-KINASE; FATTY-ACID; YEAST SNF1; SACCHAROMYCES-CEREVISIAE; NPY/AGRP NEURONS; UPSTREAM KINASE; SKELETAL-MUSCLE; MESSENGER-RNA; RAT-LIVER; LIFE-SPAN;

D O I：

10.1152/physiol.00050.2013

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

AMP-activated protein kinase appears to have evolved in single-celled eukaryotes as an adenine nucleotide sensor that maintains energy homeostasis at the cellular level. However, during evolution of more complex multicellular organisms, the system has adapted to interact with hormones so that it also plays a key role in balancing energy intake and expenditure at the whole body level.

引用

页码：99 / 107

页数：9

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