Characterization of cyclodextrin-carbopol interactions by DSC and FTIR

被引：31
作者：
Rodríguez-Tenreiro, C [1 ]
Alvarez-Lorenzo, C [1 ]
Concheiro, A [1 ]
Torres-Labandeira, JJ [1 ]
机构：
[1] Univ Santiago de Compostela, Fac Farm, Dept Farm & Tecnol Farmaceut, Santiago De Compostela 15782, Spain
来源：
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2004年 / 77卷 / 02期
关键词：
carbopol; cyclodextrin; DSC; film; freeze-dried; FTIR; glass-transition; Lorentzian deconvolution;
D O I：
10.1023/B:JTAN.0000038981.30494.f4
中图分类号：
O414.1 [热力学];
学科分类号：
摘要：
The interactions between Carbopol and beta-cyclodextrin (BCD) or hydroxypropyl-beta-cyclodextrin (HPBCD) were studied by differential scanning calorimetry (DSC) and FTIR spectroscopy. Aqueous solutions of both components were desiccated by freeze-drying or heating in an oven (films) at various temperatures. The use of different drying procedures allowed their influence on the interactions to be studied. The evolution of the Carbopol glass-transition was also evaluated by DSC using first heating runs up to different temperatures. Disappearance of the Carbopol glass-transition was observed in the freeze-dried systems prepared with either of the cyclodextrins and in the films that contained HPBCD. The changes in the FTIR band of Carbopol at 1700 cm(-1) confirmed the existence of interactions with both cyclodextrins, especially with HPBCD. This information may be useful for optimising the solubilizing capacity and controlled release performance of aqueous Carbopol-cyclodextrin systems.
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收藏
页码：403 / 411
页数：9
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