Phospholipid flippases in membrane remodeling and transport carrier biogenesis

被引：41

作者：

Best, Jordan T. ^{[1
]}

Xu, Peng ^{[1
]}

Graham, Todd R. ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Biol Sci, 221 Kirkland Hall, Nashville, TN 37235 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2019年 / 59卷

基金：

美国国家卫生研究院;

关键词：

PUTATIVE AMINOPHOSPHOLIPID TRANSLOCASE; BOX PROTEIN RCY1P; P-TYPE ATPASE; GOLGI NETWORK; SURFACE-CHARGE; EARLY ENDOSOME; YEAST; TRAFFICKING; RETRIEVAL; P4-ATPASE;

D O I：

10.1016/j.ceb.2019.02.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Molecular mechanisms underlying the formation of multiple classes of transport carriers or vesicles from Golgi and endosomal membranes remain poorly understood. However, one theme that has emerged over three decades is the dramatic influence of membrane lipid remodeling on transport mechanisms. A large cohort of lipid transfer proteins, lipid transporters, and lipid modifying enzymes are linked to protein sorting, carrier formation and SNARE-mediated fusion events. Here, we focus on one type of lipid transporter, phospholipid flippases in the type IV P-type ATPase (P4-ATPase) family, and discuss recent advances in defining P4-ATPase influences on membrane remodeling and vesicular transport.

引用

页码：8 / 15

页数：8

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