Pre-transplant marital status and hematopoietic cell transplantation outcomes

被引：3

作者：

Tay, J. ^{[1
]}

Beattie, S. ^{[1
]}

Bredeson, C. ^{[2
,3
]}

Brazauskas, R. ^{[4
,5
]}

He, N. ^{[4
]}

Ahmed, I. A. ^{[6
]}

Aljurf, M. ^{[34
]}

Askar, M. ^{[7
]}

Atsuta, Y. ^{[35
,36
]}

Badawy, S. ^{[8
,9
]}

Barata, A. ^{[39
]}

Beitinjaneh, A. M. ^{[10
]}

Bhatt, N. S. ^{[11
]}

Buchbinder, D. ^{[12
]}

Cerny, J. ^{[13
]}

Ciurea, S. ^{[14
]}

D'Souza, A. ^{[4
]}

Dalal, J. ^{[15
]}

Farhadfar, N. ^{[16
]}

Freytes, C. O. ^{[17
]}

Ganguly, S. ^{[18
]}

Gergis, U. ^{[19
]}

Gerull, S. ^{[41
]}

Lazarus, H. M. ^{[20
]}

Hahn, T. ^{[21
]}

Hong, S. ^{[22
]}

Inamoto, Y. ^{[37
]}

Khera, N. ^{[23
]}

Kindwall-Keller, T. ^{[24
]}

Kamble, R. T. ^{[7
]}

Knight, J. M. ^{[25
]}

Koleva, Y. N. ^{[26
]}

Kumar, A. ^{[27
]}

Kwok, J. ^{[42
]}

Murthy, H. S. ^{[16
]}

Olsson, R. F. ^{[43
,44
]}

Angel Diaz-Perez, M. ^{[40
]}

Rizzieri, D. ^{[28
]}

Seo, S. ^{[38
]}

Chhabra, S. ^{[4
]}

Schoemans, H. ^{[45
,46
]}

Schouten, H. C. ^{[47
]}

Steinberg, A. ^{[29
]}

Sullivan, K. M. ^{[38
]}

Szer, J. ^{[49
,50
]}

Szwajcer, D. ^{[51
]}

Ulrickson, M. L. ^{[30
]}

Verdonck, L. F. ^{[48
]}

Wirk, B. ^{[31
]}

Wood, W. A. ^{[32
]}

机构：

[1] Univ Calgary, Tom Baker Canc Ctr, 1331 29 St NW, Calgary, AB T2N 4N2, Canada

[2] Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada

[3] Ottawa Hosp Res Inst, Ottawa, ON, Canada

[4] Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA

[5] Med Coll Wisconsin, Inst Hlth & Equ, Div Biostat, Milwaukee, WI 53226 USA

[6] Childrens Mercy Hosp & Clin, Dept Hematol Oncol & Bone Marrow Transplantat, Kansas City, MO USA

[7] Baylor Univ, Dept Pathol & Lab Med, Med Ctr, Dallas, TX USA

[8] Ann & Robert H Lurie Childrens Hosp Chicago, Div Hematol Oncol & Stem Cell Transplant, Chicago, IL 60611 USA

[9] Northwestern Univ, Dept Pediat, Feinberg Sch Med, Chicago, IL 60611 USA

[10] Univ Miami, Miami, FL USA

[11] St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA

[12] Childrens Hosp Orange Cty, Div Pediat Hematol, Orange, CA 92668 USA

[13] Univ Massachusetts, Med Ctr, Dept Med, Div Hematol Oncol, Worcester, MA USA

[14] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[15] Rainbow Babies & Childrens Hosp, 2101 Adelbert Rd, Cleveland, OH 44106 USA

[16] Univ Florida, Div Hematol Oncol, Coll Med, Gainesville, FL USA

[17] Texas Transplant Inst, San Antonio, TX USA

[18] Univ Kansas Hlth Syst, Div Hematol Malignancy & Cellular Therapeut, Kansas City, KS USA

[19] Weill Cornell Med Ctr, Haematol Malignancies & Bone Marrow Transplant, Dept Med Oncol, New York Presbyterian Hosp, New York, NY USA

[20] Case Western Reserve Univ, Cleveland, OH 44106 USA

[21] Roswell Pk Canc Inst, Dept Med, Buffalo, NY USA

[22] Cleveland Clin Taussig Canc Ctr, Cleveland, OH USA

[23] Mayo Clin, Dept Hematol Oncol, Phoenix, AZ USA

[24] Univ Virginia Hlth Syst, Div Hematol Oncol, Charlottesville, VA USA

[25] Med Coll Wisconsin, Dept Psychiat, Milwaukee, WI 53226 USA

[26] Tulane Canc Ctr, New Orleans, LA USA

[27] Tufts Med Ctr, Philadelphia, PA USA

[28] Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA

[29] Mt Sinai Hosp, Div Hematol & Oncol, New York, NY USA

[30] Banner MD Anderson Canc Ctr, Gilbert, AZ USA

[31] Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA

[32] Univ N Carolina, Div Hematol Oncol, Dept Med, Chapel Hill, NC 27515 USA

[33] Univ Maryland, Dept Med, Div Hematol Oncol, Greenebaum Comprehens Canc Ctr, Baltimore, MD 21201 USA

[34] King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia

[35] Japanese Data Ctr Hematopoiet Cell Transplantat, Nagoya, Aichi, Japan

[36] Nagoya Univ, Grad Sch Med, Nagoya, Aichi, Japan

[37] Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan

[38] Dokkyo Med Univ, Dept Hematol & Oncol, Mibu, Tochigi, Japan

[39] Hosp Santa Creu & Sant Pau, Barcelona, Spain

[40] Hosp Infantil Univ Nino Jesus, Dept Hematol Oncol, Madrid, Spain

[41] Univ Hosp, Dept Hematol, Basel, Switzerland

[42] Queen Mary Hosp, Dept Pathol, Div Transplantat & Immunogenet, Hong Kong, Peoples R China

[43] Karolinska Inst, Dept Lab Med, Stockholm, Sweden

[44] Uppsala Univ, Ctr Clin Res Sormland, Uppsala, Sweden

[45] Univ Hosp Leuven, Leuven, Belgium

[46] Katholieke Univ Leuven, Leuven, Belgium

[47] Acad Ziekenhuis, Dept Hematol, Maastricht, Netherlands

[48] Isala Clin, Dept Hematol Oncol, Zwolle, Netherlands

[49] Peter MacCallum Canc Ctr, Clin Haematol, Victoria, Australia

[50] Royal Melbourne Hosp, Victoria, Australia

来源：

CURRENT ONCOLOGY | 2020年 / 27卷 / 06期

关键词：

Hematopoietic cell transplantation; marital status; overall survival; graft-versus-host disease; registries; PATIENT-REPORTED OUTCOMES; SOCIOECONOMIC-STATUS; CLINICAL-OUTCOMES; CANCER-PATIENTS; SOCIAL SUPPORT; SURVIVAL; IMPACT; CAREGIVERS; INSURANCE; BLOOD;

D O I：

10.3747/co.27.6327

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background Evidence about the impact of marital status before hematopoietic cell transplantation (HCT) on outcomes after HCT is conflicting. Methods We identified patients 40 years of age and older within the Center for International Blood and Marrow Transplant Research registry who underwent HCT between January 2008 and December 2015. Marital status before HCT was declared as one of: married or living with a partner, single (never married), separated or divorced, and widowed. We performed a multivariable analysis to determine the association of marital status with outcomes after HCT. Results We identified 10,226 allogeneic and 5714 autologous HCT cases with, respectively, a median follow-up of 37 months (range: 1-102 months) and 40 months (range: 1-106 months). No association between marital status and overall survival was observed in either the allogeneic (p = 0.58) or autologous (p = 0.17) setting. However, marital status was associated with grades 2-4 acute graft-versus-host disease (GVHD), p < 0.001, and chronic GVHD, p = 0.04. The risk of grades 2-4 acute GVHD was increased in separated compared with married patients [hazard ratio (FIR): 1.13; 95% confidence interval (CI): 1.03 to 1.24], and single patients had a reduced risk of grades 2-4 acute GVHD (FIR: 0.87; 95% CI: 0.77 to 0.98). The risk of chronic GVHD was lower in widowed compared with married patients (FIR: 0.82; 95% CI: 0.67 to 0.99). Conclusions Overall survival after HCT is not influenced by marital status, but associations were evident between marital status and grades 2-4 acute and chronic GVHD. To better appreciate the effects of marital status and social support, future research should consider using validated scales to measure social support and patient and caregiver reports of caregiver commitment, and to assess health-related quality of life together with health care utilization.

引用

页码：E596 / E606

页数：11

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