Why nanoparticles prefer liver macrophage cell uptake in vivo

被引：123
作者：
Ngo, Wayne [1 ,2 ]
Ahmed, Sara [1 ,2 ,4 ]
Blackadar, Colin [1 ,2 ]
Bussin, Bram [1 ,2 ]
Ji, Qin [1 ,2 ]
Mladjenovic, Stefan M. [1 ,2 ]
Sepahi, Zahra [1 ,2 ]
Chan, Warren C. W. [1 ,2 ,3 ]
机构：
[1] Univ Toronto, Inst Biomed Engn, Toronto, ON M5S 3G9, Canada
[2] Univ Toronto, Terrence Donnelly Ctr Cellular & Biomol Res, Toronto, ON M5S 3E1, Canada
[3] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada
[4] Univ Toronto, MD PhD Program, 1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2022年 / 185卷
基金：
加拿大自然科学与工程研究理事会;
关键词：
Drug delivery; Nanoparticles; Macrophages; Liver; Mononuclear-phagocyte system; STERICALLY STABILIZED LIPOSOMES; IRON-OXIDE NANOPARTICLES; KUPFFER CELLS; POLYETHYLENE-GLYCOL; GOLD NANOPARTICLES; AMPHOTERICIN-B; TUMOR UPTAKE; RETICULOENDOTHELIAL SYSTEM; POLYMERIC NANOPARTICLES; HEPATIC RECRUITMENT;
D O I：
10.1016/j.addr.2022.114238
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Effective delivery of therapeutic and diagnostic nanoparticles is dependent on their ability to accumulate in diseased tissues. However, most nanoparticles end up in liver macrophages regardless of nanoparticle design after administration. In this review, we describe the interactions of liver macrophages with nanoparticles. Liver macrophages have significant advantages in interacting with circulating nanoparti-cles over most target cells and tissues in the body. We describe these advantages in this article. Understanding these advantages will enable the development of strategies to overcome liver macro-phages and deliver nanoparticles to targeted diseased tissues effectively. Ultimately, these approaches will increase the therapeutic efficacy and diagnostic signal of nanoparticles.(c) 2022 Elsevier B.V. All rights reserved.
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页数：12
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