Particle Induced Toxicity in Relation to Transition Metal and Polycyclic Aromatic Hydrocarbon Contents

被引:81
作者
Gerlofs-Nijland, Miriam E. [1 ]
Rummelhard, Melina
Boere, A. John F. [1 ]
Leseman, Daan L. A. C.
Duffin, Rodger [2 ,3 ]
Schins, Roel P. F. [3 ]
Borm, Paul J. A. [4 ]
Sillanpaa, Markus [5 ]
Salonen, Raimo O. [6 ]
Cassee, Flemming R. [1 ]
机构
[1] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands
[2] Univ Edinburgh, Edinburgh EH8 9YL, Midlothian, Scotland
[3] Inst Urnweltmed Forsch, Dusseldorf, Germany
[4] Ctr Erpertise Life Sci, Heerlen, Netherlands
[5] Finnish Meteorol Inst, FIN-00101 Helsinki, Finland
[6] Natl Inst Hlth & Welf, Kuopio, Finland
关键词
OIL FLY-ASH; PARTICULATE AIR-POLLUTION; INFLAMMATORY RESPONSES; PULMONARY INFLAMMATION; URBAN ENVIRONMENTS; EPITHELIAL-CELLS; DIESEL EXHAUST; TERM EXPOSURE; MATTER; COARSE;
D O I
10.1021/es803176k
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Exposure to ambient particulate matter (PM) is statistically significantly associated with morbidity and mortality. The objectives of this study were (a) to investigate in vivo pulmonary and systemic cytotoxicity and inflammatory activity in compromised animals exposed to PM and (b) to investigate the relationships of the outcomes to the chemical compositions of particular polycyclic aromatic hydrocarbons (PAH) and transition metals in the PM, The PM samples were collected in European cities representing contrasting situations. Exposure of spontaneously hypertensive rats (7 mg of PM/kg) resulted in pulmonary inflammation, cellular toxicity and the induction of blood fibrinogen. Coarse PM generally caused stronger effects per mg than fine particles. Positive correlations between lactate dehydrogenase, proteins, and some inflammation parameters and the particle metal and PAH content were found. PM rich in PAH also led to increased blood fibrinogen. Removal of particles but not the organics (i.e., PAH) of a sample led to reduced inflammation in the lungs. The present study highlights the importance of metals as well as PM-bound PAH in particle biological outcomes. It supports the hypothesis that, on an equal mass basis, particle health effects differ due to differences in compositions and size.
引用
收藏
页码:4729 / 4736
页数:8
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