α-Alkylation of Ketones with Secondary Alcohols Catalyzed by Well-Defined Cp*CoIII-Complexes

被引：68

作者：

Chakraborty, Priyanka ^{[1
]}

Gangwar, Manoj Kumar ^{[1
]}

Emayavaramban, Balakumar ^{[1
]}

Manoury, Eric ^{[2
]}

Poli, Rinaldo ^{[2
]}

Sundararaju, Basker ^{[1
]}

机构：

[1] Indian Inst Technol Kanpur, Dept Chem, Kanpur 208016, Uttar Pradesh, India

[2] Univ Toulouse, UPS, INPT, Fine CNRS,LCC, 205 Route Narbonne, F-31077 Toulouse 4, France

来源：

CHEMSUSCHEM | 2019年 / 12卷 / 15期

关键词：

alkylation; cobalt; ketones; secondary alcohols; alpha-alkylation; H BOND FUNCTIONALIZATION; BORROWING HYDROGEN; COBALT; DEHYDROGENATION; CONVERSION; NITRILES; ETHANOL; ESTERS; ACTIVATION; ANNULATION;

D O I：

10.1002/cssc.201900990

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Although alpha-alkylation of ketones with primary alcohols by transition-metal catalysis is well-known, the same process with secondary alcohols is arduous and complicated by self-condensation. Herein a well-defined, high-valence cobalt(III)-catalyst was applied for successful alpha-alkylation of ketones with secondary alcohols. A wide-variety of secondary alcohols, which include cyclic, acyclic, symmetrical, and unsymmetrical compounds, was employed as alkylating agents to produce beta-alkyl aryl ketones.

引用

页码：3463 / 3467

页数：5

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