Predictive Factors for Completion of TPF Induction Chemotherapy in Patients With Locally Advanced Head and Neck Cancer

被引：5

作者：

Nakano, Kenji ^{[1
]}

Seto, Akira ^{[2
]}

Sasaki, Toru ^{[2
]}

Shimbashi, Wataru ^{[2
]}

Fukushima, Hirofumi ^{[2
]}

Yonekawa, Hiroyuki ^{[2
]}

Mitani, Hiroki ^{[2
]}

Takahashi, Shunji ^{[1
]}

机构：

[1] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Med Oncol, Tokyo 1350063, Japan

[2] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Head & Neck Surg, Tokyo, Japan

来源：

ANTICANCER RESEARCH | 2019年 / 39卷 / 08期

基金：

日本学术振兴会;

关键词：

Head and neck cancer; induction chemotherapy; docetaxel; cisplatin; fluorouracil; SQUAMOUS-CELL CARCINOMA; CONCURRENT CHEMORADIOTHERAPY; ORGAN PRESERVATION; TRIAL; METAANALYSIS; CETUXIMAB; PHASE-3;

D O I：

10.21873/anticanres.13601

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Induction therapy with docetaxel, cisplatin and fluorouracil (TPF) is a treatment option for locally advanced head and neck cancer (LAHNC), but it is not known which patients are appropriate for TPF. Patients and Methods: We retrospectively reviewed the records of patients with LAHNC who underwent induction TPF, and evaluated factors predictive of the completion of TPF treatment (defined as >= 3 cycles administered). Results: Of the total 93 enrolled patients, 73 (78.5%) achieved therapy completion. In a multivariate analysis, hypolaryngeal/laryngeal primary tumor site was a negative predictive factor (hazard ratio(HR)=0.32, 95% confidence interval(CI)=0.11-0.96, p=0.041) and body mass index >= 22 kg/m(2) was a positive predictive factor (hazard ratio=3.51, 95% confidence intervaI=1.04-11.83, p=0.043) of TPF completion. Conclusion: For patients with LAHNC, oropharyngeal primary tumor site and high body mass index can be used to predict TPF completion and may contribute to decisions on the indications for TPF in terms of safety and tolerability.

引用

页码：4337 / 4342

页数：6

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