Recent advances in the development of aryl-based foldamers

被引：303

作者：

Saraogi, Ishu ^{[1
]}

Hamilton, Andrew D. ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, New Haven, CT 06511 USA

来源：

CHEMICAL SOCIETY REVIEWS | 2009年 / 38卷 / 06期

基金：

美国国家卫生研究院;

关键词：

DE-NOVO DESIGN; PHENYLENE ETHYNYLENE OLIGOMERS; ALPHA/BETA-PEPTIDE FOLDAMERS; HELICAL MOLECULAR STRANDS; AROMATIC AMIDE FOLDAMERS; SOLID-PHASE SYNTHESIS; AMINO-ACIDS; SECONDARY STRUCTURES; AQUEOUS-MEDIA; SIDE-CHAINS;

D O I：

10.1039/b819597h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In recent years, significant effort has gone into making synthetic oligomers that can attain well-defined conformations analogous to the folding of biomolecules. The diversity of the structural building blocks ranges from peptidic and other aliphatic repeat units to aromatic ones, which do not have a natural counterpart. In this critical review, we will focus on the developments in aromatic foldamers in the last two years and their potential applications. This review will be of interest to people working on the structural and functional mimicry of biomolecules and will, we hope, stimulate further research into novel applications (149 references).

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页码：1726 / 1743

页数：18

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