CuBr-Mediated Oxyalkylation of Vinylarenes under Aerobic Conditions via Cleavage of sp3 C-H Bonds α to Oxygen

被引：122

作者：

Cheng, Kai ^{[1
]}

Huang, Lehao ^{[1
]}

Zhang, Yuhong ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 13期

关键词：

CATALYZED DIRECT ARYLATION; DEHYDROGENATIVE-COUPLING CDC; OXIDATIVE CYANATION; HYDROGEN-PEROXIDE; CONJUGATED DIENES; MOLECULAR-OXYGEN; TERTIARY-AMINES; ACTIVATION; FUNCTIONALIZATION; ALKENYLATION;

D O I：

10.1021/ol900947d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel difunctionalization reaction of vinylarenes with cyclic ethers has been developed by copper catalysis via direct activation of alpha-sp(3) C-H bonds of oxygen in the presence of 1-1.2 equiv of TBHP under mild aerobic conditions. The reaction shows excellent regioselectivities and good functional group tolerance to give the oxyalkylated products of vinylarenes.

引用

页码：2908 / 2911

页数：4

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