Microtubules: forgotten players in the apoptotic execution phase

被引:43
作者
Moss, David K. [1 ]
Lane, Jon D. [1 ]
机构
[1] Univ Bristol, Sch Med & Vet Sci, Dept Biochem, Bristol BS8 1TD, Avon, England
基金
英国惠康基金;
关键词
D O I
10.1016/j.tcb.2006.05.005
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
A cell entering the execution phase of apoptosis (regulated cell death) undergoes characteristic rearrangements, in which the cytoskeleton has major roles. Historically, this reorganisation has been attributed entirely to actomyosin contractility, with microtubule and intermediate filament systems both reported to be lost at an early stage. However, recent results indicate that microtubule networks re-form during the later stages of apoptosis and assist in the dispersal of nuclear and cellular fragments - steps that are thought to be important for preventing inflammation. Here, we discuss the roles of the cytoskeleton during apoptosis and challenge current thinking that actin is the sole functional component driving all major execution phase events.
引用
收藏
页码:330 / 338
页数:9
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