MicroRNAs as Therapeutic Targets and Biomarkers of Cardiovascular Disease

被引：208

作者：

Olson, Eric N. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2014年 / 6卷 / 239期

关键词：

PROLIFERATION; MIRNAS; FAMILY; HEART;

D O I：

10.1126/scitranslmed.3009008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs play central roles in cardiovascular disease, and their therapeutic manipulation raises exciting opportunities as well as challenges in the path toward clinical development.

引用

页数：5

共 28 条

[1] Atrial natriuretic peptide is negatively regulated by microRNA-425 [J].

Arora, Pankaj ;

Wu, Connie ;

Khan, Abigail May ;

Bloch, Donald B. ;

Davis-Dusenbery, Brandi N. ;

Ghorbani, Anahita ;

Spagnolli, Ester ;

Martinez, Andrew ;

Ryan, Allicia ;

Tainsh, Laurel T. ;

Kim, Samuel ;

Rong, Jian ;

Huan, Tianxiao ;

Freedman, Jane E. ;

Levy, Daniel ;

Miller, Karen K. ;

Hata, Akiko ;

del Monte, Federica ;

Vandenwijngaert, Sara ;

Swinnen, Melissa ;

Janssens, Stefan ;

Holmes, Tara M. ;

Buys, Emmanuel S. ;

Bloch, Kenneth D. ;

Newton-Cheh, Christopher ;

Wang, Thomas J. .

JOURNAL OF CLINICAL INVESTIGATION, 2013, 123 (08) :3378-3382

[2] MicroRNAs: Target Recognition and Regulatory Functions [J].

Bartel, David P. .

CELL, 2009, 136 (02) :215-233

[3] Vascular microRNAs [J].

Bonauer, Angelika ;

Boon, Reinier A. ;

Dimmeler, Stefanie .

CURRENT DRUG TARGETS, 2010, 11 (08) :943-949

[4] MicroRNA-29 in Aortic Dilation: Implications for Aneurysm Formation [J].

Boon, Reinier A. ;

Seeger, Timon ;

Heydt, Susanne ;

Fischer, Ariane ;

Hergenreider, Eduard ;

Horrevoets, Anton J. G. ;

Vinciguerra, Manlio ;

Rosenthal, Nadia ;

Sciacca, Sergio ;

Pilato, Michele ;

van Heijningen, Paula ;

Essers, Jeroen ;

Brandes, Ralf P. ;

Zeiher, Andreas M. ;

Dimmeler, Stefanie .

CIRCULATION RESEARCH, 2011, 109 (10) :1115-U66

[5] mir-17-92 Cluster Is Required for and Sufficient to Induce Cardiomyocyte Proliferation in Postnatal and Adult Hearts [J].

Chen, Jinghai ;

Huang, Zhan-Peng ;

Seok, Hee Young ;

Ding, Jian ;

Kataoka, Masaharu ;

Zhang, Zheng ;

Hu, Xiaoyun ;

Wang, Gang ;

Lin, Zhiqiang ;

Wang, Si ;

Pu, Willam T. ;

Liao, Ronglih ;

Wang, Da-Zhi .

CIRCULATION RESEARCH, 2013, 112 (12) :1557-+

[6] MicroRNA Regulation of Cardiovascular Development [J].

Cordes, Kimberly R. ;

Srivastava, Deepak .

CIRCULATION RESEARCH, 2009, 104 (06) :724-732

[7] Circulating MicroRNAs Novel Biomarkers and Extracellular Communicators in Cardiovascular Disease? [J].

Creemers, Esther E. ;

Tijsen, Anke J. ;

Pinto, Yigal M. .

CIRCULATION RESEARCH, 2012, 110 (03) :483-495

[8] Nfat and miR-25 cooperate to reactivate the transcription factor Hand2 in heart failure [J].

Dirkx, Ellen ;

Gladka, Monika M. ;

Philippen, Leonne E. ;

Armand, Anne-Sophie ;

Kinet, Virginie ;

Leptidis, Stefanos ;

el Azzouzi, Hamid ;

Salic, Kanita ;

Bourajjaj, Meriem ;

da Silva, Gustavo J. J. ;

Olieslagers, Serve ;

van der Nagel, Roel ;

de Weger, Roel ;

Bitsch, Nicole ;

Kisters, Natasja ;

Seyen, Sandrine ;

Morikawa, Yuka ;

Chanoine, Christophe ;

Heymans, Stephane ;

Volders, Paul G. A. ;

Thum, Thomas ;

Dimmeler, Stefanie ;

Cserjesi, Peter ;

Eschenhagen, Thomas ;

Martins, Paula A. da Costa ;

De Windt, Leon J. .

NATURE CELL BIOLOGY, 2013, 15 (11) :1282-U62

[9] A Human 3′ miR-499 Mutation Alters Cardiac mRNA Targeting and Function [J].

Dorn, Gerald W., II ;

Matkovich, Scot J. ;

Eschenbacher, William H. ;

Zhang, Yan .

CIRCULATION RESEARCH, 2012, 110 (07) :958-U161

[10] Functional screening identifies miRNAs inducing cardiac regeneration [J].

Eulalio, Ana ;

Mano, Miguel ;

Dal Ferro, Matteo ;

Zentilin, Lorena ;

Sinagra, Gianfranco ;

Zacchigna, Serena ;

Giacca, Mauro .

NATURE, 2012, 492 (7429) :376-+

← 1 2 3 →