Central prostaglandin D2 exhibits anxiolytic-like activity via the DP1 receptor in mice

被引：23
|
作者：
Zhao, Hui [1 ,3 ]
Ohinata, Kousaku [1 ,3 ]
Yoshikawa, Masaaki [1 ,2 ,3 ]
机构：
[1] Kyoto Univ, Grad Sch Agr, Div Food Sci & Biotechnol, Kyoto 6110011, Japan
[2] Osaka Univ, Grad Sch Engn, Frontier Res Ctr, Suita, Osaka 5650871, Japan
[3] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama, Japan
来源：
PROSTAGLANDINS & OTHER LIPID MEDIATORS | 2009年 / 88卷 / 3-4期
基金：
日本科学技术振兴机构;
关键词：
PGD(2); Anxiolytic-like activity; DP1; receptor; Adenosine A(2A) receptor; gamma-Aminobutyric acid; GABA(A) receptor; ENHANCES MEMORY CONSOLIDATION; SLEEP-WAKE REGULATION; D SYNTHASE; RAT-BRAIN; CELLS; EXPRESSION; RUBISCO; SYSTEM; CRTH2; EOSINOPHILS;
D O I：
10.1016/j.prostaglandins.2008.10.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We found that prostaglandin (PG) D-2, the most abundant PG produced in the central nervous system (CNS), exhibited anxiolytic-like activity at a dose of 10-100 pmol/mouse after intracerebroventricular (i.c.v.) administration in the elevated plus-maze test in mice. A DP1 receptor-selective agonist, BW245C, mimicked the anxiolytic-like activity of PGD(2) while a DP2 receptor agonist 13.14-dihydro-15-keto-PGD(2) was inactive, The anxiolytic-like activity of PGD(2) was blocked by a DP1 antagonist, BWA868C, suggesting that PGD(2)-induced anxiolytic-like activity was mediated by the DP1 receptor. Adenosine A(2A) or GABA(A) receptor antagonists, SCH58261 or bicuculline, respectively, also blocked its anxiolytic-like activity. Taken together,centrally administered PGD(2) may induce anxiolytic-like activity via the A(2A) acid GABA(A) receptors, downstream of the DP1 receptor. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：68 / 72
页数：5
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