Increased levels of plasma thrombomodulin are associated with vascular and all-cause mortality in patients on long-term anticoagulant treatment

被引：1
|
作者：
Jansson, JH [1 ]
Boman, K [1 ]
Brannstrom, M [1 ]
Nilsson, TK [1 ]
机构：
[1] UMEA UNIV HOSP,DEPT CLIN CHEM,S-90185 UMEA,SWEDEN
来源：
EUROPEAN HEART JOURNAL | 1996年 / 17卷 / 10期
关键词：
anticoagulants; vascular mortality; risk factors; thrombomodulin;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background The aim of the study was to test if plasma levels of thrombomodulin could predict mortality in 209 patients on long-term anticoagulant treatment followed up for 3 . 8 years. Methods and Results The thrombomodulin level was 60 . 9+/-29 . 8 mu g, l(-1) for all 45 patients who died and 60 . 5+/-30 . 5 mu g, l(-1) for the 38 vascular deaths, compared to 52 . 3+/-20 . 7 mu g,l(-1) for the 164 survivors. We found that, in Cox regression analyses; all-cause (P=0 . 025) and vascular mortality (P=0 . 042) was significantly and independently associated with increased levels of thrombomodulin. Conclusions The level of plasma thrombomodulin can predict all-cause and vascular mortality in patients on long-term anticoagulant treatment.
引用
收藏
页码：1503 / 1505
页数：3
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