Sequence variation in the hpd gene of nonencapsulated Haemophilus influenzae isolated from patients with chronic bronchitis

被引：9
作者：
Duim, B [1 ]
Ruiter, P [1 ]
Bowler, LD [1 ]
Dankert, J [1 ]
vanAlphen, L [1 ]
机构：
[1] UNIV AMSTERDAM,ACAD MED CTR,DEPT MED MICROBIOL,NL-1105 AZ AMSTERDAM,NETHERLANDS
来源：
GENE | 1997年 / 191卷 / 01期
关键词：
PCR; DNA sequencing; protein D; microbial pathogenesis;
D O I：
10.1016/S0378-1119(97)00030-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The molecular diversity of protein D of nonencapsulated Haemophilus influenzae strains isolated from persistently infected patients with chronic bronchitis was studied by sequencing the hpd gene of four independently obtained isolates. The nucleotide (nt) sequences of the hpd genes of two strains were identical. The other two hpd sequences showed nt substitutions which were mostly synonymous. As a consequence the deduced amino acid (aa) sequences differed from the consensus sequence only by a few aa. No changes in the hpd genes were observed among the four variants of the four strains persisting in chronic bronchitis patients for 9, 11, 8 and 3 months, respectively, although variation in their major outer membrane proteins P2 and P5 occurred. We conclude that the hpd gene is conserved during chronic infections of nonencapsulated H. influenzae. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：57 / 60
页数：4
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