Polymeric micelles from poly(ethylene glycol)-poly(amino acid) block copolymer for drug and gene delivery

被引：181

作者：

Osada, Kensuke ^{[1
,3
]}

Christie, R. James ^{[1
]}

Kataoka, Kazunori ^{[1
,2
,3
]}

机构：

[1] Univ Tokyo, Dept Mat Engn, Grad Sch Engn, Bunkyo Ku, Tokyo 1138656, Japan

[2] Univ Tokyo, Ctr Dis Biol & Integrat Med, Grad Sch Med, Bunkyo Ku, Tokyo 1138656, Japan

[3] Univ Tokyo, Ctr Nanobio Integrat, Bunkyo Ku, Tokyo 1138656, Japan

来源：

JOURNAL OF THE ROYAL SOCIETY INTERFACE | 2009年 / 6卷

关键词：

nanomedicine; drug delivery systems; polymeric micelle; non-viral gene delivery; block copolymer; cancer therapy; POLYION COMPLEX MICELLES; PEGYLATED POLYPLEX MICELLES; INCORPORATING PLASMID DNA; CROSS-LINKED CORE; IN-VIVO; SUPRAMOLECULAR NANOCARRIER; PHOTODYNAMIC THERAPY; ANTITUMOR-ACTIVITY; SOLID TUMORS; SELECTIVE DELIVERY;

D O I：

10.1098/rsif.2008.0547.focus

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dramatic advances in biological research have revealed the mechanisms underlying many diseases at the molecular level. However, conventional techniques may be inadequate for direct application of this new knowledge to medical treatments. Nanobiotechnology, which integrates biology with the rapidly growing field of nanotechnology, has great potential to overcome many technical problems and lead to the development of effective therapies. The use of nanobiotechnology in drug delivery systems (DDS) is attractive for advanced treatment of conditions such as cancer and genetic diseases. In this review paper for a special issue on biomaterial research in Japan, we discuss the development of DDS based on polymeric micelles mainly in our group for anti-cancer drug and gene delivery, and also address our challenges associated with developing polymeric micelles as super-functionalized nanodevices with intelligent performance.

引用

页码：S325 / S339

页数：15

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