Mouse neuroinvasive phenotype of West Nile virus strains varies depending upon virus genotype

被引：200

作者：

Beasley, DWC

Li, L

Suderman, MT

Barrett, ADT

机构：

[1] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA

[2] Univ Texas, Med Branch, WHO, Collaborating Ctr Trop Dis, Galveston, TX 77555 USA

来源：

VIROLOGY | 2002年 / 296卷 / 01期

关键词：

D O I：

10.1006/viro.2002.1372

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Despite recent advances in the genetics of West Nile l virus, relatively little is known about the molecular basis of virulence of this virus. In particular, although the genotype of the WN virus strain that was recently introduced into North America has been determined, there have been few experimental studies on the virulence phenotype of the virus. We compared genetic and neurovirulence properties of 19 strains of WN virus, including 2 from North America, and observed significant differences in their neuroinvasive phenotype in mice and hamsters that correlated with virus genotype. Virus isolated in North America was found to be highly neuroinvasive with a lack of age-related resistance to infection in mice normally associated with mosquito-borne flaviviruses. (C) 2002 Elsevier Science (USA).

引用

页码：17 / 23

页数：7

共 43 条

[1] Extensive nucleotide changes and deletions within the envelope glycoprotein gene of Euro-African West Nile viruses [J].