Synthesis, characterization and cytotoxicity of cyclopentadienyl ruthenium(II) complexes containing carbohydrate-derived ligands

被引：26
|
作者：
Florindo, Pedro [1 ]
Marques, Ines J. [2 ]
Nunes, Carla D. [2 ]
Fernandes, Ana C. [1 ]
机构：
[1] Univ Lisbon, Inst Super Tecn, Ctr Quim Estrutural, P-1049001 Lisbon, Portugal
[2] Univ Lisbon, Fac Ciencias, Ctr Quim & Bioquim, P-1749016 Lisbon, Portugal
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2014年 / 760卷
关键词：
Ruthenium(II); Cyclopentadienyl; Carbohydrates; Organometallic; Cytotoxicity; BIOLOGICALLY IMPORTANT LIGANDS; CANCER-CELL-GROWTH; IN-VITRO; DERIVATIVE COMPLEXES; ANTICANCER ACTIVITY; METAL-COMPLEXES; INHIBITION; PHOSPHITES; CHEMISTRY; CLUSTER;
D O I：
10.1016/j.jorganchem.2013.09.004
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
We here report the synthesis of new cyclopentadienyl ruthenium(II) complexes of general formula [(eta(5)-C5H5)Ru(PP)(L)](+) (PP = two triphenylphosphine, 1,2-diphenylphosphinoethane), isolated as PF6- salts, with L being galactose and fructose carbohydrate derivative ligands, N-coordinated to the metal centre by nitrile, tetrazole and 1,3,4-oxadiazole moieties. The ten new organometallic compounds were fully characterized by FT-IR, H-1, C-13, and P-31 NMR spectroscopies, and by elemental analysis. The cytotoxicity of the ruthenium(II) compounds was tested on HeLa cancer cells (cervical carcinoma), unveiling IC50 values in the low micromolar range. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：240 / 247
页数：8
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