Synthesis and studies on some new fluorine containing triazolothiadiazines as possible antibacterial, antifungal and anticancer agents

被引：131

作者：

Holla, B. Shivarama ^{[1
]}

Rao, B. Sooryanarayana

Sarojini, B. K.

Akberali, P. M.

Kumari, N. Suchetha

机构：

[1] Mangalore Univ, Dept Postgrad Studies & Res Chem, Mangalagangothri 574199, India

[2] Apotex Pharmachem India Pvt Ltd, Bangalore 562158, Karnataka, India

[3] PA Coll Engn, Dept Chem, Mangalore 574153, India

[4] KS Hegde Med Acad, Dept Biochem, Deralakatte 574160, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 05期

关键词：

1,2,4-triazoles; 1,3,4-thiadiazines; antibacterial agents; antifungal agents; anticancer screening;

D O I：

10.1016/j.ejmech.2006.02.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthesis of a series of 7-arylidene-6-(2,4-dichlorophenyl)-3-aryloxymethyl/anilinomethyl-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazines (3) by the condensation of 3-aryl-l-(2,4-dichloro-5-fluorophenyl)-2-bromo-propen-1-one (1) and 4-amino-5-mercapto-3-aryloxymethyl/anilinomethyl-1,2,4-triazoles (2) is described. The newly synthesized compounds were characterized by elemental analysis IR, H-1 NMR and mass spectral data. These compounds were tested for their antimicrobial activities against Escherichia coli, Staplylococcus aureus (Smith), Psuedomonas aeruginosa (Gessard), Bacillus subtilis and Candida albicans. Some of the newly synthesized compounds were also screened for their anticancer activity. Among them compounds 3m, 3o, 3q showed in vitro anticancer activity. (c) 2006 Elsevier SAS. All rights reserved.

引用

页码：657 / 663

页数：7