Genetics of testicular germ cell tumors

被引：7
作者：
Verdorfer, I. [1 ]
机构：
[1] Med Univ Innsbruck, Dept Med Genet Mol & Klin Pharmakol, Sekt Humangenet, A-6020 Innsbruck, Austria
来源：
PATHOLOGE | 2014年 / 35卷 / 03期
关键词：
Cytogenetic; Chromosome; Spermatocytic seminoma; Teratoma; Embryonal carcinoma; METASTATIC SPERMATOCYTIC SEMINOMA; EXTREMELY RARE DISEASE; CARCINOMA IN-SITU; PATHOGENESIS; VARIANTS; CANCER; IDENTIFICATION; CYTOGENETICS; CHROMOSOMES; EXPRESSION;
D O I：
10.1007/s00292-014-1897-z
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Testicular cancer is by far the most common neoplasm among young males between the ages of 20 and 40 years and with an increasing incidence rate worldwide. Congenital malformations of the male genitals, such as cryptorchidism or inguinal hernia are established risk factors. Men with a family history of testicular cancer are also associated with an increased risk of the disease. In the testes more than 90 % of tumors develop from germ cells (progenitor cells) and represent a histologically heterogeneous group. Germ cell tumors in extragonadal localizations are rare. Isochromosome i(12p), the typical marker chromosome in testicular germ cell tumors, occurs as an early event in tumorigenesis. Spermatocytic seminoma is a rare variant of germ cell tumors and according to the current classification is a distinct entity with different morphological, clinical and also cytogenetical features compared with other germ cell tumors.
引用
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页码：218 / +
页数：5
相关论文
共 34 条
  • [1] [Anonymous], PATHOLOGY GENETICS T
  • [2] Molecular biology of testicular germ cell tumors: Unique features awaiting clinical application
    Boublikova, Ludmila
    Buchler, Tomas
    Stary, Jan
    Abrahamova, Jitka
    Trka, Jan
    [J]. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2014, 89 (03) : 366 - 385
  • [3] Chaganti RSK, 2000, CANCER RES, V60, P1475
  • [4] Meta-analysis identifies four new loci associated with testicular germ cell tumor
    Chung, Charles C.
    Kanetsky, Peter A.
    Wang, Zhaoming
    Hildebrandt, Michelle A. T.
    Koster, Roelof
    Skotheim, Rolf I.
    Kratz, Christian P.
    Turnbull, Clare
    Cortessis, Victoria K.
    Bakken, Anne C.
    Bishop, D. Timothy
    Cook, Michael B.
    Erickson, R. Loren
    Fossa, Sophie D.
    Jacobs, Kevin B.
    Korde, Larissa A.
    Kraggerud, Sigrid M.
    Lothe, Ragnhild A.
    Loud, Jennifer T.
    Rahman, Nazneen
    Skinner, Eila C.
    Thomas, Duncan C.
    Wu, Xifeng
    Yeager, Meredith
    Schumacher, Fredrick R.
    Greene, Mark H.
    Schwartz, Stephen M.
    McGlynn, Katherine A.
    Chanock, Stephen J.
    Nathanson, Katherine L.
    [J]. NATURE GENETICS, 2013, 45 (06) : 680 - +
  • [5] Cytogenetics of the progression of adult testicular germ cell tumors
    deJong, B
    vanEchten, J
    Looijenga, LHJ
    vanKessel, AG
    Oosterhuis, JW
    [J]. CANCER GENETICS AND CYTOGENETICS, 1997, 95 (01) : 88 - 95
  • [6] Molecular pathogenesis and molecular prognosis factors of the testicular tumor
    Heidenreich, A
    Kuczyk, M
    Albers, P
    [J]. UROLOGE A, 1998, 37 (06): : 593 - +
  • [7] Common variation in KITLG and at 5q31.3 predisposes to testicular germ cell cancer
    Kanetsky, Peter A.
    Mitra, Nandita
    Vardhanabhuti, Saran
    Li, Mingyao
    Vaughn, David J.
    Letrero, Richard
    Ciosek, Stephanie L.
    Doody, David R.
    Smith, Lauren M.
    Weaver, JoEllen
    Albano, Anthony
    Chen, Chu
    Starr, Jacqueline R.
    Rader, Daniel J.
    Godwin, Andrew K.
    Reilly, Muredach P.
    Hakonarson, Hakon
    Schwartz, Stephen M.
    Nathanson, Katherine L.
    [J]. NATURE GENETICS, 2009, 41 (07) : 811 - U65
  • [8] The roles of supernumerical X chromosomes and XIST expression in testicular germ cell tumors
    Kawakami, T
    Okamoto, K
    Sugihara, H
    Hattori, T
    Reeve, AE
    Ogawa, O
    Okada, Y
    [J]. JOURNAL OF UROLOGY, 2003, 169 (04) : 1546 - 1552
  • [9] Variants in or near KITLG, BAK1, DMRT1, and TERT-CLPTM1L predispose to familial testicular germ cell tumour
    Kratz, Christian P.
    Han, Summer S.
    Rosenberg, Philip S.
    Berndt, Sonja I.
    Burdett, Laurie
    Yeager, Meredith
    Korde, Larissa A.
    Mai, Phuong L.
    Pfeiffer, Ruth
    Greene, Mark H.
    [J]. JOURNAL OF MEDICAL GENETICS, 2011, 48 (07) : 473 - 476
  • [10] Gonadoblastoma in a patient with del(9)(p22) and sex reversal: report of a case and review of the literature
    Livadas, S
    Mavrou, A
    Sofocleous, C
    van Vliet-Constantinidou, C
    Dracopoulou, M
    Dacou-Voutetakis, C
    [J]. CANCER GENETICS AND CYTOGENETICS, 2003, 143 (02) : 174 - 177
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