CXCR3-CXCL9: It's All in the Tumor

被引：50

作者：

Humblin, Etienne ^{[1
]}

Kamphorst, Alice O. ^{[2
]}

机构：

[1] Icahn Sch Med Mt Sinai, Precis Immunol Inst, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Tisch Canc Inst, Precis Immunol Inst, Dept Oncol Sci, New York, NY 10029 USA

来源：

IMMUNITY | 2019年 / 50卷 / 06期

关键词：

T-CELL TRAFFICKING; RESPONSES;

D O I：

10.1016/j.immuni.2019.05.013

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this issue of Immunity, Chow et al. (2019) show that the CXCR3-CXCL9 axis is required for reinvigoration of intratumoral CD8(+) T cell responses in response to PD-1 blockade and demonstrate that local guidance to dendritic cells, rather than recruitment of T cells into the tumor, underlies the importance of this chemokine axis.

引用

页码：1347 / 1349

页数：3

共 10 条

[1] Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy [J].

Chow, Melvyn T. ;

Ozga, Aleksandra J. ;

Servis, Rachel L. ;

Frederick, Dennie T. ;

Lo, Jennifer A. ;

Fisher, David E. ;

Freeman, Gordon J. ;

Boland, Genevieve M. ;

Luster, Andrew D. .

IMMUNITY, 2019, 50 (06) :1498-+

[2] CD8 T Cell Exhaustion in Chronic Infection and Cancer: Opportunities for Interventions [J].

Hashimoto, Masao ;

Kamphorst, Alice O. ;

Im, Se Jin ;

Kissick, Haydn T. ;

Pillai, Rathi N. ;

Ramalingam, Suresh S. ;

Araki, Koichi ;

Ahmed, Rafi .

ANNUAL REVIEW OF MEDICINE, VOL 69, 2018, 69 :301-318

[3] Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy [J].

Im, Se Jin ;

Hashimoto, Masao ;

Gerner, Michael Y. ;

Lee, Junghwa ;

Kissick, Haydn T. ;

Urger, Matheus C. B. ;

Shan, Qiang ;

Hale, J. Scott ;

Lee, Judong ;

Nasti, Tahseen H. ;

Sharpe, Arlene H. ;

Freeman, Gordon J. ;

Germain, Ronald N. ;

Nakaya, Helder I. ;

Xue, Hai-Hui ;

Ahmed, Rafi .

NATURE, 2016, 537 (7620) :417-+

[4] Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent [J].

Kamphorst, Alice O. ;

Wieland, Andreas ;

Nasti, Tahseen ;

Yang, Shu ;

Zhang, Ruan ;

Barber, Daniel L. ;

Konieczny, Bogumila T. ;

Daugherty, Candace Z. ;

Koenig, Lydia ;

Yu, Ke ;

Sica, Gabriel L. ;

Sharpe, Arlene H. ;

Freeman, Gordon J. ;

Blazar, Bruce R. ;

Turka, Laurence A. ;

Owonikoko, Taofeek K. ;

Pillai, Rathi N. ;

Ramalingam, Suresh S. ;

Araki, Koichi ;

Ahmed, Rafi .

SCIENCE, 2017, 355 (6332) :1423-1427

[5] Peripheral Prepositioning and Local CXCL9 Chemokine-Mediated Guidance Orchestrate Rapid Memory CD8+ T Cell Responses in the Lymph Node [J].

Kastenmueller, Wolfgang ;

Brandes, Marlene ;

Wang, Ze ;

Herz, Jasmin ;

Egen, Jackson G. ;

Germain, Ronald N. .

IMMUNITY, 2013, 38 (03) :502-513

[6] Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints [J].

Mikucki, M. E. ;

Fisher, D. T. ;

Matsuzaki, J. ;

Skitzki, J. J. ;

Gaulin, N. B. ;

Muhitch, J. B. ;

Ku, A. W. ;

Frelinger, J. G. ;

Odunsi, K. ;

Gajewski, T. F. ;

Luster, A. D. ;

Evans, S. S. .

NATURE COMMUNICATIONS, 2015, 6

[7] Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade [J].

Miller, Brian C. ;

Sen, Debattama R. ;

Al Abosy, Rose ;

Bi, Kevin ;

Virkud, Yamini V. ;

LaFleur, Martin W. ;

Yates, Kathleen B. ;

Lako, Ana ;

Felt, Kristen ;

Naik, Girish S. ;

Manos, Michael ;

Gjini, Evisa ;

Kuchroo, Juhi R. ;

Ishizuka, Jeffrey J. ;

Collier, Jenna L. ;

Griffin, Gabriel K. ;

Maleri, Seth ;

Comstock, Dawn E. ;

Weiss, Sarah A. ;

Brown, Flavian D. ;

Panda, Arpit ;

Zimmer, Margaret D. ;

Manguso, Robert T. ;

Hodi, F. Stephen ;

Rodig, Scott J. ;

Sharpe, Arlene H. ;

Haining, W. Nicholas .

NATURE IMMUNOLOGY, 2019, 20 (03) :326-+

[8] Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma (vol 175, 998.e1 , 2018) [J].

Sade-Feldman, Moshe ;

Yizhak, Keren ;

Bjorgaard, Stacey L. ;

Ray, John P. ;

de Boer, Carl G. ;

Jenkins, Russell W. ;

Lieb, David J. ;

Chen, Jonathan H. ;

Frederick, Dennie T. ;

Barzily-Rokni, Michal ;

Freeman, Samuel S. ;

Reuben, Alexandre ;

Hoover, Paul J. ;

Villani, Alexandra-Chloe ;

Ivanova, Elena ;

Portell, Andrew ;

Lizotte, Patrick H. ;

Aref, Amir R. ;

Eliane, Jean-Pierre ;

Hammond, Marc R. ;

Vitzthum, Hans ;

Blackmon, Shauna M. ;

Li, Bo ;

Gopalakrishnan, Vancheswaran ;

Reddy, Sangeetha M. ;

Cooper, Zachary A. ;

Paweletz, Cloud P. ;

Barbie, David A. ;

Stemmer-Rachamimov, Anat ;

Flaherty, Keith T. ;

Wargo, Jennifer A. ;

Boland, Genevieve M. ;

Sullivan, Ryan J. ;

Getz, Gad ;

Hacohen, Nir .

CELL, 2019, 176 (1-2) :404-404

[9] Expansion and Activation of CD103+ Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition [J].

Salmon, Helene ;

Idoyaga, Juliana ;

Rahman, Adeeb ;

Leboeuf, Marylene ;

Remark, Romain ;

Jordan, Stefan ;

Casanova-Acebes, Maria ;

Khudoynazarova, Makhzuna ;

Agudo, Judith ;

Tung, Navpreet ;

Chakarov, Svetoslav ;

Rivera, Christina ;

Hogstad, Brandon ;

Bosenberg, Marcus ;

Hashimoto, Daigo ;

Gnjatic, Sacha ;

Bhardwaj, Nina ;

Palucka, Anna Karolina ;

Brown, Brian D. ;

Brody, Joshua ;

Ginhoux, Florent ;

Merad, Miriam .

IMMUNITY, 2016, 44 (04) :924-938

[10] Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy [J].

Spranger, Stefani ;

Dai, Daisy ;

Horton, Brendan ;

Gajewski, Thomas F. .

CANCER CELL, 2017, 31 (05) :711-+

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