Highly selective, sensitive and fluorescent sensing of dimeric G-quadruplexes by a dimeric berberine

被引：40

作者：

Zhou, Chun-Qiong ^{[1
]}

Yang, Jian-Wei ^{[1
]}

Dong, Cheng ^{[1
]}

Wang, Yong-Min ^{[1
]}

Sun, Bin ^{[1
]}

Chen, Jin-Xiang ^{[1
]}

Xu, Ya-Shi ^{[1
]}

Chen, Wen-Hua ^{[1
]}

机构：

[1] Southern Med Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab New Drug Screening, Guangzhou 510515, Guangdong, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 01期

基金：

中国国家自然科学基金;

关键词：

DNA-CLEAVING ACTIVITIES; PARALLEL G-QUADRUPLEXES; LIGHT-UP PROBE; TELOMERIC DNA; C-MYC; RECOGNITION SPECIFICITY; STABILIZING LIGANDS; THIOFLAVIN T; C9ORF72; GENE; ON PROBE;

D O I：

10.1039/c5ob01723h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper describes the highly selective, sensitive and topology-specific fluorescent sensing of dimeric G-quadruplexes by a polyether-tethered dimeric berberine 1. Compound 1 displays high selectivity for dimeric G-quadruplexes over monomeric ones, and can be lit up by dimeric G-quadruplexes, in particular by the one linked with one TTA subunit. In addition, it shows no effect on the topology or thermal stability of the G-quadruplexes.

引用

页码：191 / 197

页数：7

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