Bacterial phospholipases and pathogenesis

被引：135
|
作者：
Schmiel, DH
Miller, VL
机构：
[1] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Pediat, St Louis, MO 63110 USA
来源：
MICROBES AND INFECTION | 1999年 / 1卷 / 13期
关键词：
bacteria; phospholipase; pathogenesis;
D O I：
10.1016/S1286-4579(99)00205-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Phospholipases are produced from a diverse group of bacterial pathogens causing very different diseases. In some cases, secreted phospholipases appear to be the major cause of pathophysiological effects. Yet in other cases, phospholipases are key virulence factors, contributing to bacterial survival or dissemination without causing tissue destruction. Perhaps the most intriguing aspect of phospholipases as virulence factors is their potential to interfere with cellular signaling cascades and to modulate the host immune response. (C) 1999 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码：1103 / 1112
页数：10
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