Managing Patients With Relapsed Small-Cell Lung Cancer

被引：45

作者：

Gong, Jun ^{[1
]}

Salgia, Ravi ^{[1
]}

机构：

[1] City Hope Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA

来源：

JOURNAL OF ONCOLOGY PRACTICE | 2018年 / 14卷 / 06期

基金：

美国国家卫生研究院;

关键词：

PHASE-II TRIAL; OPEN-LABEL; 3RD-LINE CHEMOTHERAPY; 2ND-LINE CHEMOTHERAPY; AMERICAN-COLLEGE; TOPOTECAN; MULTICENTER; IRINOTECAN; MANAGEMENT; TEMOZOLOMIDE;

D O I：

10.1200/JOP.18.00204

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Despite high response rates to initial therapy, relapses are common in patients with small-cell lung cancer (SCLC). Systemic therapy after first-line failure remains important in the treatment paradigm of SCLC. Reinitiation of a previously administered first-line chemotherapy regimen is recommended for relapse > 6 months from completion of initial therapy. For relapse 6 months of initial therapy, sequential therapy with single agents is recommended. Clinical trial enrollment should be considered at all stages of treatment of SCLC. This review highlights the available treatment options in relapsed SCLC. In particular, we focus on prospective clinical trials demonstrating activity for the most commonly used agents in this setting. We end with a discussion on future directions and emerging targets with potential to improve outcomes in relapsed SCLC.

引用

页码：359 / +

页数：9

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