Cheating evolution: engineering gene drives to manipulate the fate of wild populations

被引:277
作者
Champer, Jackson [1 ]
Buchman, Anna [1 ]
Akbari, Omar S. [1 ]
机构
[1] Univ Calif Riverside, Dept Entomol, Ctr Dis Vector Res, Inst Integrat Genome Biol, Riverside, CA 92521 USA
基金
美国国家卫生研究院;
关键词
GENETICALLY-MODIFIED MOSQUITOS; HOMING ENDONUCLEASE GENES; LIFE-SHORTENING WOLBACHIA; MUTAGENIC CHAIN-REACTION; HUMAN MALARIA MOSQUITO; CRISPR-CAS SYSTEM; DUAL-USE CONCERNS; AEDES-AEGYPTI; MEIOTIC DRIVE; SEX-RATIO;
D O I
10.1038/nrg.2015.34
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Engineered gene drives - the process of stimulating the biased inheritance of specific genes - have the potential to enable the spread of desirable genes throughout wild populations or to suppress harmful species, and may be particularly useful for the control of vector-borne diseases such as malaria. Although several types of selfish genetic elements exist in nature, few have been successfully engineered in the laboratory thus far. With the discovery of RNA-guided CRISPR-Cas9 (clustered regularly interspaced short palindromic repeats-CRISPR-associated 9) nucleases, which can be utilized to create, streamline and improve synthetic gene drives, this is rapidly changing. Here, we discuss the different types of engineered gene drives and their potential applications, as well as current policies regarding the safety and regulation of gene drives for the manipulation of wild populations.
引用
收藏
页码:146 / 159
页数:14
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