An Increasing Incidence of Upper Gastrointestinal Disorders Over 23 Years: A Prospective Population-Based Study in Sweden

被引：13

作者：

Andreasson, Anna ^{[1
,2
,3
]}

Talley, Nicholas J. ^{[4
,5
]}

Walker, Marjorie M. ^{[4
,5
]}

Jones, Michael P. ^{[2
]}

Platts, Loretta G. ^{[1
]}

Wallner, Bengt ^{[6
]}

Kjellstrom, Lars ^{[7
]}

Hellstrom, Per M. ^{[8
]}

Forsberg, Anna ^{[3
]}

Agreus, Lars ^{[9
]}

机构：

[1] Stockholm Univ, Stress Res Inst, Dept Psychol, Stockholm, Sweden

[2] Macquarie Univ, Dept Psychol, N Ryde, NSW, Australia

[3] Karolinska Inst, Dept Med Solna, Solna, Sweden

[4] Univ Newcastle, Fac Hlth & Med, Newcastle, NSW, Australia

[5] NHMRC Ctr Res Excellence Digest Hlth, Newcastle, NSW, Australia

[6] Umea Univ, Umea, Sweden

[7] Gastromottagningen City, Stockholm, Sweden

[8] Uppsala Univ, Uppsala, Sweden

[9] Karolinska Inst, Dept Neurobiol Care Sci & Soc, Huddinge, Sweden

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2021年 / 116卷 / 01期

关键词：

PREVALENCE; DYSPEPSIA; HISTORY; ADULTS;

D O I：

10.14309/ajg.0000000000000972

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

INTRODUCTION: We hypothesized that the prevalence of functional dyspepsia and gastroesophageal reflux disease in the community may be increasing. METHODS: Randomly selected adults were surveyed on 4 occasions: 1988 (n = 1,151, 21-79 years, response rate [rr] = 90%), 1989 (n = 1,097, 22-80 years, rr = 87%), 1995 (n = 1,139, 20-85 years, rr = 76%), and 2011 (n = 1,175, 20-93 years, rr = 63%). RESULTS: In functional dyspepsia, the odds of postprandial distress syndrome tripled over 23 years' follow-up (odds ratio [OR]: 3.55; 95% confidence interval [CI]: 2.60-4.84, mixed-effect regression analysis), whereas a small decrease in epigastric pain syndrome was observed (OR: 0.65, 95% CI: 0.42-1.00). The odds of reporting gastroesophageal reflux disease doubled (OR: 2.02; 95% CI: 1.50-2.73). DISCUSSION: The underlying mechanisms behind the increase in postprandial distress syndrome and gastroesophageal reflux disease remain to be determined.

引用

页码：210 / 213

页数：4

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