Copper-Catalyzed and Indium-Mediated Methoxycarbonylation of Unactivated Alkyl Iodides with Balloon CO

被引：24

作者：

Chen, Yanchi ^{[1
,2
]}

Su, Lei ^{[1
,2
]}

Gong, Hegui ^{[1
,2
]}

机构：

[1] Shanghai Univ, Sch Mat Sci & Engn, Ctr Supramol Chem & Catalysis, 99 Shang Da Rd, Shanghai 200444, Peoples R China

[2] Shanghai Univ, Dept Chem, 99 Shang Da Rd, Shanghai 200444, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 12期

关键词：

RADICAL-ADDITION; SATURATED ALCOHOLS; CARBON-MONOXIDE; CARBONYLATION; METAL; ALKOXYCARBONYLATION; COMPLEXES; PRECURSOR; REAGENTS; PD;

D O I：

10.1021/acs.orglett.9b01573

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This work emphasizes the synthesis of alkyl esters via Cu-catalyzed and In-mediated alkoxycarbonylation of unactivated alkyl iodides in the presence of In or InI. The reactions were suitable for the preparation of primary, secondary, and even tertiary alkyl esters, representing an exceptionally rare example for the creation of quaternary carbon centers upon formation of esters. The preliminary mechanistic studies indicated that alkyl radicals were involved, and Cu/In/CO played a cooperative role in the carbonylation event.

引用

页码：4689 / 4693

页数：5

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