Prolonged Protective Immunity Induced by Mild SARS-CoV-2 Infection of K18-hACE2 Mice

被引：3

作者：

Bar-On, Liat ^{[1
]}

Aftalion, Moshe ^{[1
]}

Makdasi, Efi ^{[2
]}

Gur, David ^{[1
]}

Alcalay, Ron ^{[1
]}

Cohen, Hila ^{[1
]}

Beth-Din, Adi ^{[1
]}

Rosenfeld, Ronit ^{[1
]}

Achdout, Hagit ^{[2
]}

Bar-Haim, Erez ^{[1
]}

Falach, Reut ^{[1
]}

Chitlaru, Theodor ^{[1
]}

Cohen, Ofer ^{[1
]}

机构：

[1] Israel Inst Biol Res, Biochem & Mol Genet Dept, IL-74100 Ness Ziona, Israel

[2] Israel Inst Biol Res, Infect Dis Dept, IL-74100 Ness Ziona, Israel

来源：

VACCINES | 2022年 / 10卷 / 04期

关键词：

SARS-CoV-2; COVID-19; K18-hACE2; mice; mild infection;

D O I：

10.3390/vaccines10040613

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Longevity of the immune response following viral exposure is an essential aspect of SARS-CoV-2 infection. Mild SARS-CoV-2 infection of K18-hACE2 mice was implemented for evaluating the mounting and longevity of a specific memory immune response. We show that the infection of K18-hACE2 mice induced robust humoral and cellular immunity (systemic and local), which persisted for at least six months. Virus-specific T cells and neutralizing antibody titers decreased over time, yet their levels were sufficient to provide sterile immunity against lethal rechallenge six months post-primary infection. The study substantiates the role of naturally induced immunity against SARS-CoV-2 infection for preventing recurring morbidity.

引用

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