Non-invasive tests for clinically significant portal hypertension after HCV cure

被引：59

作者：

Semmler, Georg ^{[1
,2
]}

Lens, Sabela ^{[3
,4
,5
]}

Meyer, Elias L. ^{[6
]}

Baiges, Anna ^{[3
,4
,5
]}

Alvardo-Tapias, Edilmar ^{[5
,7
]}

Llop, Elba ^{[5
,8
]}

Tellez, Luis ^{[9
]}

Schwabl, Philipp ^{[1
,2
,10
,11
]}

Mauro, Ezequiel ^{[12
,13
]}

Escude, Laia ^{[3
,4
,5
]}

Diez, Cristina ^{[14
,15
]}

Ibanez-Samaniego, Luis ^{[5
,14
,16
]}

Puente, Angela ^{[17
]}

Fortea, Jose Ignacio ^{[17
]}

Abadia, Marta ^{[18
]}

Zanetto, Alberto ^{[19
]}

Conthe, Andres ^{[5
,16
]}

Hernandez-Evole, Helena ^{[3
,4
]}

Scheid, Irina Sofia Luzko ^{[3
,4
]}

Jia, Jidong ^{[20
,21
,22
]}

Yoshiji, Hitoshi ^{[23
]}

Francque, Sven M. ^{[24
,25
,26
,27
]}

Tsochatzis, Emmanuel A. ^{[10
,11
,28
]}

Russo, Francesco Paolo ^{[18
]}

Crespo, Gonzalo ^{[3
,4
,5
]}

Forns, Xavier ^{[3
,4
,5
]}

Banares, Rafael ^{[14
,15
,16
,29
]}

Villanueva, Candid ^{[5
,7
]}

Hernandez-Gea, Virginia ^{[3
,4
,5
]}

Reiberger, Thomas ^{[1
,2
]}

Bosch, Jaume ^{[3
,4
,5
,30
]}

Pagan, Juan Carlos Garcia ^{[3
,4
,5
]}

Mandorfer, Mattias ^{[1
,2
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Wahringer Gurtel 18-20, A-1090 Vienna, Austria

[2] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Vienna Hepat Hemodynam Lab, Vienna, Austria

[3] Univ Barcelona, Hosp Clin, Liver Unit, Hlth Care Provider European Reference Network Rar, Barcelona, Spain

[4] Univ Barcelona, August Pi i Sunyer Biomed Res Inst IDIBAPS, Barcelona, Spain

[5] Inst Salud Carlos III, Ctr Invest Biomed Red Enfermedades Hepat & Digest, Madrid, Spain

[6] Med Univ Vienna, Ctr Med Stat Informat & Intelligent Syst, Inst Med Stat, Vienna, Austria

[7] Autonomous Univ Barcelona, Hosp Santa Creu & St Pau, Hosp St Pau Biomed Res Inst IIB St Pau, Barcelona, Spain

[8] Univ Autonoma Madrid, Hosp Univ Puerta De Hierro Majadahonda, Liver Unit, Madrid, Spain

[9] Univ Alcala, Hosp Univ Ramon y Cajal, Dept Gastroenterol & Hepatol, IRYCIS, Madrid, Spain

[10] Royal Free Hosp, UCL Inst Liver & Digest Hlth, London, England

[11] UCL, London, England

[12] Hosp Italiano Buenos Aires, Liver Unit, Buenos Aires, DF, Argentina

[13] Hosp Italiano Buenos Aires, Liver Transplant Unit, Buenos Aires, DF, Argentina

[14] Hosp Gen Univ Gregorio Maranon, Unidad Enfermedades Infecciosas VIH, Madrid, Spain

[15] Inst Invest Sanitaria Gregorio Maranon IiSGM, Madrid, Spain

[16] Hosp Gen Univ Gregorio Maranon, Liver Unit, Madrid, Spain

[17] Hosp Univ Marques de Valdecilla, Serv Aparato Digest, Santander, Spain

[18] Hosp Univ La Paz, Serv Aparato Digest, Madrid, Spain

[19] Padua Univ Hosp, Dept Surg Oncol & Gastroenterol, Gastroenterol & Multivisceral Transplant Unit, Padua, Italy

[20] Capital Medial Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing, Peoples R China

[21] Beijing Key Lab Translat Med Liver Cirrhosis, Beijing, Peoples R China

[22] Natl Clin Res Ctr Digest Dis, Beijing, Peoples R China

[23] Nara Med Univ, Dept Gastroenterol, Nara, Japan

[24] Antwerp Univ Hosp, Dept Gastroenterol & Hepatol, Antwerp, Belgium

[25] Univ Antwerp, Fac Med & Hlth Sci, Lab Expt Med & Paediat LEMP, Antwerp, Belgium

[26] Univ Antwerp, InflaMed Ctr Excellence, Antwerp, Belgium

[27] Univ Antwerp, Translat Sci Inflammat & Immunol, Antwerp, Belgium

[28] Royal Free Hosp, Sheila Sherlock Liver Ctr, London, England

[29] Univ Complutense Madrid, Madrid, Spain

[30] Univ Bern, Dept Visceral Surg & Med, Inselspital, Bern, Switzerland

来源：

JOURNAL OF HEPATOLOGY | 2022年 / 77卷 / 06期

关键词：

HVPG; hepatic venous pressure gradient; CSPH; LSM; liver stiffness measurement; transient elastography; platelet count; NIT; chronic hepatitis C; sus-tained virologic response; SVR; aetiological cure; VENOUS-PRESSURE GRADIENT; SUSTAINED VIROLOGICAL RESPONSE; INTERFERON-FREE REGIMENS; ORAL ANTIVIRAL THERAPY; CHRONIC HEPATITIS-C; LIVER STIFFNESS; DECOMPENSATION; CIRRHOSIS; RISK; HEMODYNAMICS;

D O I：

10.1016/j.jhep.2022.08.025

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background & Aims: Non-invasive tests (NITs) for clinically significant portal hypertension (CSPH; hepatic venous pressure gradient [HVPG] >-10 mmHg) have predominantly been studied in patients with active HCV infection. Investigations after HCV cure are limited and have yielded conflicting results. We conducted a pooled analysis to determine the diagnostic/prognostic utility of liver stiffness measurement (LSM)/platelet count (PLT) in this setting. Methods: A total of 418 patients with pre-treatment HVPG >- 6 mmHg who achieved sustained virological response (SVR) and underwent post-treatment HVPG measurement were assessed, of whom 324 (HVPG/NIT-cohort) also had paired data on pre-/post-treatment LSM/PLT. The derived LSM/PLT criteria were then validated against the direct endpoint decompensation in 755 patients with compensated advanced chronic liver disease (cACLD) with SVR (cACLD-validation-cohort). Results: HVPG/NIT-cohort: Among patients with cACLD, the pre-/post-treatment prevalence of CSPH was 80%/54%. The correlation between LSM/HVPG increased from pre- to posttreatment (r = 0.45 vs. 0.60), while that of PLT/HVPG remained unchanged. For given LSM/PLT values, HVPG tended to be lower

引用

页码：1573 / 1585

页数：14

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