Myeloid sarcoma of the small bowel associated with a CBFβ/MYH11 fusion and inv(16)(p13q22): a case report

被引：12

作者：

McKenna, M.

Arnold, C.

Catherwood, M. A.

Humphreys, M. W. ^{[1
]}

Cuthbert, R. J. G.

Bueso-Ramos, C. ^{[2
]}

McManus, D. T. ^{[1
]}

机构：

[1] Belfast City Hosp, Belfast Hlth & Social Care Trust, Reg Genet Ctr, Belfast BT9 7AD, Antrim, North Ireland

[2] Univ Texas Houston, MD Anderson Canc Ctr, Houston, TX 77030 USA

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2009年 / 62卷 / 08期

关键词：

GRANULOCYTIC-SARCOMA; SMALL-INTESTINE; LEUKEMIA; GENE;

D O I：

10.1136/jcp.2008.063669

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

This report describes a case of aleukaemic myeloid sarcoma of the small intestine in a 50-year-old woman presenting with small bowel obstruction. Fluorescence in situ hybridisation analysis of interphase nuclei revealed a split CBF beta signal, consistent with an underlying inversion of chromosome 16, inv(16)(p13q22). The resultant type A CBF beta/MYH11 transcript was detected by reverse transcriptase PCR. Immunohistochemistry with the AH107 antibody to the CBF beta-SMMHC chimeric protein showed strong nuclear staining of the tumour cell nuclei. This represents the first use of this antibody in the diagnosis of this subtype of myeloid sarcoma in the small intestine.

引用

页码：757 / 759

页数：3

共 11 条

[1]

Arber D A., 2008, WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, P109

[2] Granulocytic sarcoma of mesentery in acute myeloid leukemia with CBFB/MYH11 fusion gene but not inv(16) chromosome:: Case report and review of literature [J].