The Current State of Pediatric Acute Respiratory Distress Syndrome

被引：40
作者：
Orloff, Kirsten E. [1 ]
Turner, David A. [1 ]
Rehder, Kyle J. [1 ]
机构：
[1] Duke Childrens Hosp, Dept Pediat, Div Pediat Crit Care Med, DUMC Box 3046, Durham, NC 27710 USA
来源：
PEDIATRIC ALLERGY IMMUNOLOGY AND PULMONOLOGY | 2019年 / 32卷 / 02期
关键词：
pediatric; acute respiratory distress syndrome; Pediatric Acute Lung Injury Consensus Conference; lung protective ventilation; oxygenation index; acute hypoxemic respiratory failure; ACUTE LUNG INJURY; FREQUENCY OSCILLATORY VENTILATION; INHALED NITRIC-OXIDE; CONVENTIONAL MECHANICAL VENTILATION; EXTRACORPOREAL MEMBRANE-OXYGENATION; NEUROMUSCULAR BLOCKING-AGENTS; END-EXPIRATORY PRESSURE; CLINICAL-OUTCOMES; INTENSIVE-CARE; PROTOCOLIZED SEDATION;
D O I：
10.1089/ped.2019.0999
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Pediatric acute respiratory distress syndrome (PARDS) is a significant cause of morbidity and mortality in children. Children with PARDS often require intensive care admission and mechanical ventilation. Unfortunately, beyond lung protective ventilation, there are limited data to support our management strategies in PARDS. The Pediatric Acute Lung Injury Consensus Conference (PALICC) offered a new definition of PARDS in 2015 that has improved our understanding of the true epidemiology and heterogeneity of the disease as well as risk stratification. Further studies will be crucial to determine optimal management for varying disease severity. This review will present the physiologic basis of PARDS, describe the unique pediatric definition and risk stratification, and summarize the current evidence for current standards of care as well as adjunctive therapies.
引用
收藏
页码：35 / 44
页数：10
相关论文
共 95 条
[1]   Inhaled Nitric Oxide for Acute Respiratory Distress Syndrome and Acute Lung Injury in Adults and Children: A Systematic Review with Meta-Analysis and Trial Sequential Analysis [J].
Afshari, Arash ;
Brok, Jesper ;
Moller, Ann M. ;
Wetterslev, Jorn .
ANESTHESIA AND ANALGESIA, 2011, 112 (06) :1411-1421
[2]  
[Anonymous], 2018, PRONE OS CILLATION P
[3]   PROSPECTIVE, RANDOMIZED COMPARISON OF HIGH-FREQUENCY OSCILLATORY VENTILATION AND CONVENTIONAL MECHANICAL VENTILATION IN PEDIATRIC RESPIRATORY-FAILURE [J].
ARNOLD, JH ;
HANSON, JH ;
TOROFIGUERO, LO ;
GUTIERREZ, J ;
BERENS, RJ ;
ANGLIN, DL .
CRITICAL CARE MEDICINE, 1994, 22 (10) :1530-1539
[4]   Pediatric Extracorporeal Life Support Organization Registry International Report 2016 [J].
Barbaro, Ryan P. ;
Paden, Matthew L. ;
Guner, Yigit S. ;
Raman, Lakshmi ;
Ryerson, Lindsay M. ;
Alexander, Peta ;
Nasr, Viviane G. ;
Bembea, Melania M. ;
Rycus, Peter T. ;
Thiagarajan, Ravi R. .
ASAIO JOURNAL, 2017, 63 (04) :456-463
[5]  
BARTLETT RH, 1985, PEDIATRICS, V76, P479
[6]   Early High-Frequency Oscillatory Ventilation in Pediatric Acute Respiratory Failure A Propensity Score Analysis [J].
Bateman, Scot T. ;
Borasino, Santiago ;
Asaro, Lisa A. ;
Cheifetz, Ira M. ;
Diane, Shelley ;
Wypij, David ;
Curley, Martha A. Q. .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193 (05) :495-503
[7]   Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries [J].
Bellani, Giacomo ;
Laffey, John G. ;
Pham, Tai ;
Fan, Eddy ;
Brochard, Laurent ;
Esteban, Andres ;
Gattinoni, Luciano ;
van Haren, Frank ;
Larsson, Anders ;
McAuley, Daniel F. ;
Ranieri, Marco ;
Rubenfeld, Gordon ;
Thompson, B. Taylor ;
Wrigge, Hermann ;
Slutsky, Arthur S. ;
Pesenti, Antonio .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2016, 315 (08) :788-800
[8]   THE AMERICAN-EUROPEAN CONSENSUS CONFERENCE ON ARDS - DEFINITIONS, MECHANISMS, RELEVANT OUTCOMES, AND CLINICAL-TRIAL COORDINATION [J].
BERNARD, GR ;
ARTIGAS, A ;
BRIGHAM, KL ;
CARLET, J ;
FALKE, K ;
HUDSON, L ;
LAMY, M ;
LEGALL, JR ;
MORRIS, A ;
SPRAGG, R ;
COCHIN, B ;
LANKEN, PN ;
LEEPER, KV ;
MARINI, J ;
MURRAY, JF ;
OPPENHEIMER, L ;
PESENTI, A ;
REID, L ;
RINALDO, J ;
VILLAR, J ;
VANASBECK, BS ;
DHAINAUT, JF ;
MANCEBO, J ;
MATTHAY, M ;
MEYRICK, B ;
PAYEN, D ;
PERRET, C ;
FOWLER, AA ;
SCHALLER, MD ;
HUDSON, LD ;
HYERS, T ;
KNAUS, W ;
MATTHAY, R ;
PINSKY, M ;
BONE, RC ;
BOSKEN, C ;
JOHANSON, WG ;
LEWANDOWSKI, K ;
REPINE, J ;
RODRIGUEZROISIN, R ;
ROUSSOS, C ;
ANTONELLI, MA ;
BELOUCIF, S ;
BIHARI, D ;
BURCHARDI, H ;
LEMAIRE, F ;
MONTRAVERS, P ;
PETTY, TL ;
ROBOTHAM, J ;
ZAPOL, W .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1994, 149 (03) :818-824
[9]   The Association Between Inhaled Nitric Oxide Treatment and ICU Mortality and 28-Day Ventilator-Free Days in Pediatric Acute Respiratory Distress Syndrome* [J].
Bhalla, Anoopindar K. ;
Yehya, Nadir ;
Mack, Wendy J. ;
Wilson, Melissa L. ;
Khemani, Robinder G. ;
Newth, Christopher J. L. .
CRITICAL CARE MEDICINE, 2018, 46 (11) :1803-1810
[10]  
BIFANO E M, 1992, Pediatric Research, V31, p196A
12345678910