Serum superoxide dismutase level is a potential biomarker of disease prognosis in patients with hemorrhagic fever with renal syndrome caused by the Hantaan virus

Background Hemorrhagic fever with renal syndrome (HFRS) is a disease with increased systemic inflammation and a high fatality rate. Oxidative stress is crucial for inflammation in the pathogeneses of various diseases. We aimed to identify biomarkers of oxidative stress that may assess the severity and disease outcomes of patients with HFRS. Methods Between January 2015 and September 2018, we analyzed a retrospective cohort of 149 HFRS patients and 30 healthy individuals. Serum levels of SOD were measured using an ELISA commercial kit, and survival analysis was carried out using the Kaplan-Meier method. Results Patients with HFRS had significantly lower serum SOD levels compared with healthy controls (108.40 +/- 2.47 U/mL vs 164.23 +/- 3.82 U/mL, P < 0.01). SOD levels in patients were lower at acute than at convalescent stage (108.40 +/- 2.47 U/mL vs 138.27 +/- 2.87 U/mL, P < 0.01), and in severe and critical patients than in moderate and mild patients (89.63 +/- 2.38 U/mL vs 122.53 +/- 3.18 U/mL, P < 0.01). A serum level of SOD < 88.6 U/mL at admission was associated with a significant increase in mortality risk in HFRS patients. Conclusion Our results indicate that serum levels of SOD measured at admission can be used to assess disease severity and assign patients into high- and low-risk groups. SOD can be considered a novel biomarker of severity and outcomes in patients with HFRS.