Preparation and reactivity of [2-(3-methyl-4-nitro-isoxazol-5-yl)-vinyl]-amines

被引：3

作者：

Dere, Ravindra ^{[1
]}

Monasterolo, Claudio ^{[1
]}

Moccia, Maria ^{[1
]}

Adamo, Mauro F. A. ^{[1
]}

机构：

[1] Royal Coll Surgeons Ireland, Dept Pharmaceut & Med Chem, CSCB, Dublin 2, Ireland

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 52期

关键词：

Polyfunctional scaffolds; 4-Nitroisoxazoles; Isoxazoles; Enamines; BETA-ENAMINO ESTERS; MULTICOMPONENT SYNTHESIS; EFFICIENT SYNTHESIS; AZA-ANNULATION; ROUTE; ALPHA; REDUCTION; AMINO;

D O I：

10.1016/j.tetlet.2015.11.037

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we report our investigation into the reactivity of 5-enamino-4-nitroisoxazoles. This study revealed that the title compounds, in spite of conjugation to the 4-nitroisoxazole, displayed similar reactivity to enamines, reacting with electrophiles to form new C-C, C-N, and C-Cl bonds. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：7168 / 7171

页数：4

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