Relationship between obesity, inflammation and insulin resistance:: new concepts.

被引：17
作者：
Feve, Bruno
Bastard, Jean-Philippe
Vidal, Hubert [1 ]
机构：
[1] Univ Lyon 1, Fac Med Rene Laennec, Inra U, UMR 1236,Inserm U449, F-69372 Lyon 08, France
[2] Univ Paris 11, Inserm U693, F-94720 Le Kremlin Bicetre, France
[3] CHU Bicetre, Serv Endocrinol, F-94720 Le Kremlin Bicetre, France
[4] Univ Paris 06, Inserm U680, Fac Med St Antoine, F-75970 Paris 20, France
[5] Hop Tenon, APHP, Ser Biochim & Hormonol, F-75970 Paris 20, France
来源：
COMPTES RENDUS BIOLOGIES | 2006年 / 329卷 / 08期
关键词：
adipocyte; macrophage; obesity; diabetes; visceral adipose tissue; adipokines; metabolic syndrome;
D O I：
10.1016/j.crvi.2006.03.020
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
White adipose tissue is the main site of energy storage, but it is now recognized as an active participant in regulating physiologic and pathologic processes including immunity and inflammation. It has an endocrine function by secreting at least two main hormones, leptin and adiponectin. It can secrete other products, named adipokines, including cytokines and chemokines, involved in inflammation process. The release of adipokines by either adipocytes or adipose tissue infiltrated macrophages lead to a chronic sub-inflammatory state that could play a central role in cardiovascular complications linked to obesity and insulin resistance, a risk factor to develop type-2 diabetes.
引用
收藏
页码：587 / 597
页数：11
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