Impact of influenza treatment with oseltamivir on health, sleep and daily activities of otherwise healthy adults and adolescents

被引:20
|
作者
Bettis, Robert
Iacuzio, Dominick
Jung, Thomas
Fuchs, Rudolf
Aultman, Rick
Gyldmark, Marlene [1 ]
机构
[1] F Hoffmann La Roche & Co Ltd, Nutley, NJ USA
[2] Edmonds Family Med Clin, Washington, DC USA
[3] F Hoffmann La Roche & Co Ltd, CH-4002 Basel, Switzerland
关键词
D O I
10.2165/00044011-200626060-00004
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Objective: To determine the effect of oseltamivir (75mg twice daily) on time to return to baseline health, sleep and activity in patients with laboratory-confirmed influenza infection. Patients and methods: Data from 1642 otherwise healthy adults (aged 13-64 years), who had experienced a febrile influenza-like illness (> 38 degrees C) of up to 36 hours' duration together with at least one respiratory and one systemic/constitutional symptom, were pooled from four randomised, double-blind, placebo-controlled clinical trials. Patients in these trials had been randomised to receive either oseltamivir or placebo for 5 days and had been allowed unlimited use of symptom-relief medications. The primary analysis examined the effect of oseltamivir treatment on patients' general health status, sleep and normal activities as measured by visual analogue scales. Secondary analyses examined the possible effects of gender, influenza type, smoking, employment status and time to treatment (<= or > 24 hours) on these endpoints. Results: Oseltamivir significantly reduced the time taken to return to baseline health, sleep and activity across all pooled patients (p < 0.0001) and increased the proportion of patients returning to full activity within the first 7 days following treatment start. Gender, smoking status, time to treatment, influenza subtype and employment status had no appreciable effect on the effectiveness of oseltamivir. Conclusions: In otherwise healthy adults, oseltamivir reduces the time to return to pre-illness levels of health, sleep and activity, and may help to decrease the overall burden of influenza on society. This provides an important rationale for the early use of antiviral treatment, such as oseltamivir, for the treatment of influenza in otherwise healthy adults and adolescents.
引用
收藏
页码:329 / 340
页数:12
相关论文
共 50 条
  • [31] Sleep regularity in healthy adolescents: Associations with sleep duration, sleep quality, and mental health
    Castiglione-Fontanellaz, Chiara E. G.
    Schaufler, Samira
    Wild, Salome
    Hamann, Christoph
    Kaess, Michael
    Tarokh, Leila
    JOURNAL OF SLEEP RESEARCH, 2023, 32 (04)
  • [32] Sleep, daily activities, and their association with mood states among emerging adults
    Ari, Lilac Lev
    Shulman, Shmuel
    BIOLOGICAL RHYTHM RESEARCH, 2013, 44 (03) : 353 - 367
  • [33] Prevalence of pain and interference with daily activities and sleep in adults with cerebral palsy
    Rodby-Bousquet, Elisabet
    Alriksson-Schmidt, Ann
    Jarl, Johan
    DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY, 2021, 63 (01): : 60 - 67
  • [34] Evaluation of an activities of daily living scale for adolescents and adults with developmental disabilities
    Maenner, Matthew J.
    Smith, Leann E.
    Hong, Jinkuk
    Makuch, Renee
    Greenberg, Jan S.
    Mailick, Marsha R.
    DISABILITY AND HEALTH JOURNAL, 2013, 6 (01) : 8 - 17
  • [35] THE IMPACT OF EXPERIMENTAL SLEEP RESTRICTION ON ENDOTHELIAL FUNCTION IN HEALTHY ADOLESCENTS
    Chan, A.
    Begum, Y.
    Robertson, A.
    Walker, K.
    Westmacott, R.
    Shroff, M.
    Dlamini, N.
    Narang, I.
    SLEEP MEDICINE, 2022, 100 : S209 - S209
  • [36] Impact of early oseltamivir treatment on outcome in critically ill patients with 2009 pandemic influenza A
    Rodriguez, Alejandro
    Diaz, Emili
    Martin-Loeches, Ignacio
    Sandiumenge, Alberto
    Canadell, Laura
    Diaz, Juan J.
    Figueira, Juan C.
    Marques, Asuncion
    Alvarez-Lerma, Francisco
    Valles, Jordi
    Baladin, Barbara
    Garcia-Lopez, Fernando
    Suberviola, Borja
    Zaragoza, Rafael
    Trefler, Sandra
    Bonastre, Juan
    Blanquer, Jose
    Rello, Jordi
    JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2011, 66 (05) : 1140 - 1149
  • [37] Impact of 5 nights of sleep restriction on healthy adolescents behaviors
    Beebe, D.
    Schaffner, L.
    Ridel, S.
    McNally, K.
    Grampp, K.
    Tlustos, S.
    Raouf, A.
    SLEEP, 2007, 30 : A71 - A71
  • [38] Impact of Late Oseltamivir Treatment on Influenza Symptoms in the Outpatient Setting: Results of a Randomized Trial
    McLean, Huong Q.
    Belongia, Edward A.
    Kieke, Burney A.
    Meece, Jennifer K.
    Fry, Alicia M.
    OPEN FORUM INFECTIOUS DISEASES, 2015, 2 (03):
  • [39] A clinical trial of intravenous peramivir compared with oral oseltamivir for the treatment of seasonal influenza in hospitalized adults
    Ison, Michael G.
    Hui, David S.
    Clezy, Kate
    O'Neil, Brian J.
    Flynt, Amy
    Collis, Philip J.
    Simon, Thomas J.
    Alexander, W. James
    ANTIVIRAL THERAPY, 2013, 18 (05) : 651 - 661
  • [40] Impact of oseltamivir treatment on influenza-related lower respiratory tract complications and hospitalizations
    Kaiser, L
    Wat, C
    Mills, T
    Mahoney, P
    Ward, P
    Hayden, F
    ARCHIVES OF INTERNAL MEDICINE, 2003, 163 (14) : 1667 - 1672