Estrogen receptor-alpha (ER-α) suppresses expression of its variant ER-α36

被引：83

作者：

Zou, Yi ^{[1
]}

Ding, Ling ^{[1
]}

Coleman, Megan ^{[1
]}

Wang, Zhaoyi ^{[1
]}

机构：

[1] Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, Omaha, NE 68178 USA

来源：

FEBS LETTERS | 2009年 / 583卷 / 08期

关键词：

Promoter; Estrogen receptor; ER-alpha; 36; Breast cancer; HUMAN BREAST CARCINOMAS; ELEMENT HALF-SITE; BINDING-SITES; IDENTIFICATION; GROWTH; GENE; ACTIVATION; PATHWAYS; CANCER; WT1;

D O I：

10.1016/j.febslet.2009.03.047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recently, we identified and cloned a membrane-based estrogen receptor (ER), ER-alpha 36, which is transcribed from a previously unidentified promoter in the first intron of the original ER-alpha gene. We cloned the 5' flanking region of ER-alpha 36 and found the cloned DNA sequence possessed strong promoter activity. A single transcription initiation site was mapped and a number of putative regulatory elements for various transcription factors such as the Wilms' tumor suppressor, WT1 and estrogen receptor (ER) were identified in this region. Transient co-transfection experiments further demonstrated that ER-alpha suppresses ER-alpha 36 promoter activity in an estrogen-independent manner, which can be released by ER-alpha 36 itself. (C) 2009 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：1368 / 1374

页数：7

共 24 条

[1] Estrogen receptor α interaction with estrogen response element half-sites from the rat prolactin gene [J].

Anderson, I ;

Gorski, J .

BIOCHEMISTRY, 2000, 39 (13) :3842-3847

[2] Estrogen action and cytoplasmic signaling pathways. Part II: the role of growth factors and phosphorylation in estrogen signaling [J].

Driggers, PH ;

Segars, JH .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2002, 13 (10) :422-428

[3] Identification of a new isoform of the human estrogen receptor-alpha (hER-α) that is encoded by distinct transcripts and that is able to repress hER-α activation function 1 [J].

Flouriot, G ;

Brand, H ;

Denger, S ;

Metivier, R ;

Kos, M ;

Reid, G ;

Sonntag-Buck, V ;

Gannon, F .

EMBO JOURNAL, 2000, 19 (17) :4688-4700

[4]

Huang THM, 1997, CANCER RES, V57, P1030

[5] Estrogen receptor interaction with estrogen response elements [J].

Klinge, CM .

NUCLEIC ACIDS RESEARCH, 2001, 29 (14) :2905-2919

[6] Estrogen receptor pathways to AP-1 [J].

Kushner, PJ ;

Agard, DA ;

Greene, GL ;

Scanlan, TS ;

Shiau, AK ;

Uht, RM ;

Webb, P .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2000, 74 (05) :311-317

[7] Hypermethylation of the Wilms' tumor suppressor gene CpG island in human breast carcinomas [J].

Laux, DE ;

Curran, EM ;

Welshons, WV ;

Lubahn, DB ;

Huang, THM .

BREAST CANCER RESEARCH AND TREATMENT, 1999, 56 (01) :35-43

[8]

Lee LMJ, 2008, ANTICANCER RES, V28, P479

[9] Integration of the extranuclear and nuclear actions of estrogen [J].

Levin, ER .

MOLECULAR ENDOCRINOLOGY, 2005, 19 (08) :1951-1959

[10] Cellular functions of plasma membrane estrogen receptors [J].

Levin, ER .

STEROIDS, 2002, 67 (06) :471-475

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