Osteoarthritis joint pain: The cytokine connection

被引：230

作者：

Miller, Rachel E. ^{[1
,2
]}

Miller, Richard J. ^{[3
]}

Malfait, Anne-Marie ^{[1
,2
]}

机构：

[1] Rush Univ, Med Ctr, Dept Internal Med, Div Rheumatol, Chicago, IL 60612 USA

[2] Rush Univ, Med Ctr, Dept Biochem, Chicago, IL 60612 USA

[3] Northwestern Univ, Dept Mol Pharmacol & Biol Chem, Chicago, IL 60611 USA

来源：

CYTOKINE | 2014年 / 70卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Osteoarthritis; Pain; Chemokines; Cytokines; Animal models; NECROSIS-FACTOR-ALPHA; DORSAL-ROOT GANGLION; ANTIGEN-INDUCED ARTHRITIS; NERVE GROWTH-FACTOR; PRIMARY SENSORY NEURONS; MICROGLIAL CATHEPSIN-S; RHEUMATOID-ARTHRITIS; NEUROPATHIC PAIN; TNF-ALPHA; MECHANICAL STIMULI;

D O I：

10.1016/j.cyto.2014.06.019

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Osteoarthritis is a chronic and painful disease of synovial joints. Chondrocytes, synovial cells and other cells in the joint can express and respond to cytokines and chemokines, and all of these molecules can also be detected in synovial fluid of patients with osteoarthritis. The presence of inflammatory cytokines in the osteoarthritic joint raises the question whether they may directly participate in pain generation by acting on innervating joint nociceptors. Here, we first provide a systematic discussion of the known proalgesic effects of cytokines and chemokines that have been detected in osteoarthritic joints, including TNF-alpha, IL-1, IL-6, IL-15, IL-10, and the chemokines, MCP-1 and fractalkine. Subsequently, we discuss what is known about their contribution to joint pain based on studies in animal models. Finally, we briefly discuss limited data available from clinical studies in human osteoarthritis. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：185 / 193

页数：9

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